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Table of Contents
TYPE 1 DIABETES
Signs and Symptom
Causes
Risk Factors
Pathobiology
Type 1 Diabetes involves a combination of autoimmune, genetic and environmental factors that target the insulin producing β cells and leads to β-cell death. Several genes are associated with this disease, however, most of them are unknown by scientists. Among the few that are known, are HLA genes. These genes are found on chromosome 6 (on the short arm) and lead a 50% genetic susceptability to Type 1 diabetes. There are 2 HLA class II haplotypes, DR4-DQ8 and DR3-DQ2
