Ph.D. 2015, Biomedical Engineering, McMaster University
B.Sc. Physiotherapy, 2007, Chung Shan Medical University

Postdoctoral Fellow & instructor, 2015-2021, The Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard University

Assistant Professor
Department of Orthopaedics, Center for Musculoskeletal Research (SMD)
University of Rochester

Allison Yeh’s current research involves the project of PDT dosimetry in cancer research and integrated detection and ablation of Barrett's esophageal cell lines using the PDT photosensitizer,5-aminolevulinic acid (5-ALA). The research projects involve the use of fluorescence lifetime imaging microscopy, confocal and multiphoton microscopy, and image processing. She is also interested in other microscopic applications and computational design preferably with a focus on the applications of molecular probes, in vivo imaging, and machine learning.

Allison's main research projects include:

• Characterization of the fluorescence lifetimes of PDT photosensitizers
  
• 5-ALA based detection and laser ablation of Barrett's esophagus
  

• 2009 - 2010 Alexander Graham Bell Canada Graduate Scholarship
• 2010 - 2011 Queen Elizabeth II Graduate Scholarship in Science and Technology (QEII GSST)
• 2011 - 2012 Ontario Graduate Scholarship
• 2012 - 2014 NSERC Alexander Graham Bell Canada Graduate Scholarship
• 2014 NSERC Michael Smith Foreign Study Supplement

  
* Zhaojun Nie, Shu-Chi Allison Yeh, Michelle LePalud, Fares Badr, Frances Tse, David Armstrong, Louis W. C. Liu, M. Jamal Deen, and Qiyin Fang, "Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra," Frontiers in Physiology, 11:339, 2020,  doi.org/10.3389/fphys.2020.00339| ([[https://doi.org/10.3389/fphys.2020.00339|open access online]])

• Shu-Chi Allison Yeh, Celine S.N. Ling, David W. Andrews, Michael S. Patterson, Kevin R. Diamond, Joseph E. Hayward, David Armstrong, and Qiyin Fang, “5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett’s Esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015 (PDF).

• Shu-Chi Allison Yeh, Samir Sahli, David W. Andrews, Michael S. Patterson, David Armstrong, John Provias, and Qiyin Fang, “5-aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models,” Journal of Biomedical Optics, 20(3):036010, 2015 (PDF).

• Shu-Chi Allison Yeh, Michael S. Patterson, Joseph E. Hayward, and Qiyin Fang, “Time-resolved fluorescence in photodynamic therapy,” Photonics, 1(4): 530-564 (Open Access)

• Shu-Chi Allison Yeh, Kevin Diamond, Michael Patterson, Zhaojun Nie, Joseph Hayward, Qiyin Fang, “Monitoring Photosensitizer Uptake Using Two Photon Fluorescence Lifetime Imaging Microscopy,” Theranostics; 2(9):817-826, 2012 (Open Access).

• Regina Won Kay Leung, Shu-Chi Allison Yeh, and Qiyin Fang, “Effects of incomplete decay in fluorescence lifetime estimation,” Biomedical Optics Express 2(9):2517–2531, 2011. (PDF)

Conference Proceedings

• Pouya Rezai, Shu-Chi (Allison) Yeh, Sangeena Salam, Qiyin Fang, Bhagwati P Gupta, Ponnambalam R Selvaganapathy. Co-relation of cellular and behavioral responses of caenorhabditis elegans to pulse DC electric fields. W.2.59 (1630), MicroTAS (2012).

Conference Oral Presentations

• Shu-chi Allison Yeh, Kevin Diamond, Michael Patterson, Zhaojun Nie, Joseph Hayward, Qiyin Fang, “Monitoring Photosensitizer Uptake Using Two Photon Fluorescence Lifetime Imaging Microscopy” SPIE Photonics West Bios (Abstract #8568-37, 2013)

• Shu-chi Allison Yeh, Tony Collins, Kevin Diamond, Regina Leung, & Qiyin Fang, “Using Fluorescence Lifetime Imaging Microscopy to Monitor Photofrin Uptake, Redistribution, and Intracellular Microenvironment” 217th ECS Meeting Section: E3 - Integrated Optoelectronics 5
  
  

Conference Poster Presentations

• Shu-Chi A. Yeh, Regina W. K. Leung, Qiyin Fang, “Effects of incomplete decay in fluorescence lifetime estimation.
  • Paper NIH100-106, 7th NIH Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside, September 15 (2011)
• Shu-chi Yeh, Tony J. Collins, Kevin Diamond, Qiyin Fang. “Photofrin Uptake Monitored by FLIM”
  • in Biomedical Optics (BIOMED)/ Digital Holography and Three-Dimensional Imaging (DH) on CD-ROM (The Optical Society, Washington, DC, 2010), presentation number ISBN: 978-1-55752-887-2