ContactMailing Address
Office: ETB 405
Voice: (905) 525-9140 x 24227
Lab: (905) 963-3777
ETB 405
McMaster University
1280 Main Street West
Hamilton, ON L8S 4L7


B. S. Physics (Nankai)
M.S. Applied Physics (East Carolina University)
Ph.D. Biomedical Physics (East Carolina University)

Brief Biography

Qiyin Fang is a professor of Engineering Physics at McMaster University and held the Canada Research Chair in Biophotonics from 2005-2016. He is a member of the McMaster School of Biomedical Engineering and associate member of several other programs. Dr. Fang's current research interests include multimodality sensing and imaging technologies for biomedical applications, e.g. optical biopsy, wide-field imaging, endoscopy, microscopy, point-of-care/in-home/wearable sensing systems, and distributed environmental sensing.

Prior to his current position at McMaster, Dr. Fang was a research scientist in the Minimally Invasive Surgical Technology Institute at the Cedars-Sinai Medical Center in Los Angeles.

Dr. Fang obtained both of his graduate degrees from the East Carolina University, where he studied nanosecond laser pulse interaction with soft biological tissue. His undergraduate degree is in physics from Nankai University.

Dr. Fang is an elected fellow of the International Society for Optical Engineering (SPIE).


EP 3A03 Applications of Photonics BME 701 Introduction to Biomedical Engineering
EP 3W04/2W03 Acquisition and Analysis of
Experimental Information
ECE 778 Nanotechnology
(Nanomedicine and bionanotechnology)
EP 4I03
MP 4I03
Introduction to Biophotonics EP 6I03
MP 6I03
BME 6I03
Introduction to Biophotonics
EP 4G03 Optical Instrumentation EP 6G03 Optical Instrumentation
EP 4U02 Advanced Physics Lab
BME 707 Selected topics in biophotonics
iBEHS 1P10 Health Solution Design Projects I
iBEHS 3P04 Health Solution Design Projects III

Selected Recent Publications


  • Le V. N. Du, Manser Myla, Gurm Sunny, Wagner Ben, Hayward Joseph E., Fang Qiyin, “Calibration of Spectral Imaging Devices With Oxygenation-Controlled Phantoms: Introducing a Simple Gel-Based Hemoglobin Model,” Frontiers in Physics, 7: 192, 2019, DOI=10.3389/fphy.2019.00192 (Online)
  • Jessica Kun, Marek Smieja, Bo Xiong, Leyla Soleymani, Qiyin Fang, “The Use of Motion Analysis as Particle Biomarkers in Lensless Optofluidic Projection Imaging for Point of Care Urine Analysis,” Sci Rep 9, 17255, 2019, doi:10.1038/s41598-019-53477-8 (online)
  • Eric Mahoney, Huan-Huan Hsu, Fei Du, Bo Xiong, P. Ravi Selvaganapathy, and Qiyin Fang, “Optofluidic Dissolved Oxygen Sensing With Sensitivity Enhancement Through Multiple Reflections,” IEEE Sensors 19(22): 10452-10460, 2019, (online)
  • Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, “Cross-talk reduction in a multiplexed synchroscan streak camera with simultaneous calibration,” Opt. Express 27: 22602-22614, 2019, (online)
  • Sinead Dufour, Donna Fedorkow, Jessica Kun, Shirley S.X. Deng, & Qiyin Fang, “Exploring the Impact of a Mobile Health Solution for Postpartum Pelvic Floor Muscle Training: Pilot Randomized Controlled Feasibility Study.” JMIR MHealth and UHealth, 7(7): e12587, 2019, (online)
  • Eric Mahoney, Colleen Chau, Qiyin Fang, “Experiential learning of data acquisition and sensor networks with a cloud computing platform,” Proc. SPIE 11143, Fifteenth Conference on Education and Training in Optics and Photonics: ETOP 2019, 111433X, 2 July 2019 (online);
  • Henry Y.-H. Siu, B. Delleman, J. Langevin, Dee Mangin, Michelle Howard, Qiyin Fang, David Price, David Chan, “Demonstrating a Technology-Mediated Intervention to Support Medication Adherence in Community-Dwelling Older Adults in Primary Care: A Feasibility Study.” Gerontology and Geriatric Medicine, 5:1-11, 2019, (online)
  • Fahad Aljekhedab, Wenbin Zhang, Harold K. Haugen, Gregory R. Wohl, Munir M. El-Desouki, Qiyin Fang, “Influence of environmental conditions in bovine bone ablation by ultrafast laser,” Journal of Biophotonics, 12(6): e201800293, 2019;


  • Ramy Abdlaty, Lilian Doerwald-Munoz, Ali Madooei, Samir Sahli, Shu-Chi Allison Yeh, Josiane Zerubia, Raimond K. W. Wong, Joseph E.Hayward, Thomas J. Farrell, Qiyin Fang, “Hyperspectral Imaging and Classification for Grading Skin Erythema,” Frontiers in Physics, 6, 72, 2018, DOI:10.3389/fphy.2018.00072(Open access)
  • S. C. Goh, Y. Luan, X.g Wang, H. Du, C. Chau, H. E. Schellhorn, J. L. Brash, H. Chen, and Q. Fang, “Polydopamine-polyethylene glycol-albumin antifouling coatings on multiple substrates,” Journal of Materials Chemistry B, 6, 940-949, 2018 (Online)
  • R. Abdlaty, J. Orepoulos, P. Sinclair, R. Berman, and Q. Fang, “High throughput AOTF hyperspectral imager for randomly polarized light,” Photonics, invited paper, 5(1), 3, 2018 (Open Access)
  • N. Shalaby, A. Al-Ebraheem, D. Le, S. Cornacchi, Q. Fang, T. Farrell, P. Lovrics, G. Gohla, S. Reid, N. Hodgson, M. Farquharson, “Time-Resolved Fluorescence (TRF) and Diffuse Reflectance Spectroscopy (DRS) for Margin Analysis in Breast Cancer,” Lasers in Surgery and Medicine,50(3):236–245, 2018 (PDF)


  • Vinh Nguyen Du Le, John Provias, Naresh Murty, Michael S. Patterson, Zhaojun Nie, Joseph E. Hayward, Thomas J. Farrell, William McMillan, Wenbin Zhang, Qiyin Fang, “Dual-modality optical biopsy of glioblastomas multiforme with diffuse reflectance and fluorescence: ex vivo retrieval of optical properties,” J. Biomed. Opt. 22(2):027002, 2017; (PDF)
  • Christina M. Gabardo, Robert C. Adams-McGavin, Barnabas C. Fung, Eric J. Mahoney, Qiyin Fang, Leyla Soleymani, “Rapid prototyping of all-solution-processed multi-lengthscale electrodes using polymer-induced thin film wrinkling,” Scientific Reports 7, 42543, 2017. (Open Access)


  • Derek J. Cappon, Thomas J. Farrell, Qiyin Fang, and Joseph E. Hayward, “Distortion correction and cross-talk compensation algorithm for use with an imaging spectrometer based spatially resolved diffuse reflectance system,” Review of Scientific Instruments, 87(2):123112, 2016 (PDF)
  • Anthony Tsikouras, Pietro Peronio, Ivan Rech, Nehad Hirmiz, M. Jamal Deen, and Qiyin Fang, “Characterization of SPAD Array for Multifocal High-Content Screening Applications,” Photonics 3(4):56, 2016; doi: 10.3390/photonics3040056, (Open Access)
  • Zhaojun Nie, Vinh Nguyen Du Le ; Derek Cappon ; John Provias ; Naresh Murty ; Joseph E. Hayward ; Thomas J. Farrell ; Michael S. Patterson ; William McMillan ; Qiyin Fang, “Integrated Time-Resolved Fluorescence and Diffuse Reflectance Spectroscopy Instrument for Intraoperative Detection of Brain Tumor Margin,” IEEE Journal of Selected Topics in Quantum Electronics, 22(3): 6802109, 2016 (PDF)
  • Yushan Zhang, Benjamin R. Watts, Tianyi Guo, Zhiyi Zhang, Changqing Xu, and Qiyin Fang, “Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review,” Micromachines 7(4): 70, 2016; doi: 10.3390/mi7040070. (Open Access)


  • Vinh Nguyen Du Le, Michael S. Patterson, Thomas J. Farrell, Joseph E. Hayward, Qiyin Fang, “Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence,” Journal of Biomedical Optics 20(12), 127003, 2015. doi:10.1117/1.JBO.20.12.127003, (PDF)
  • Anthony Tsikouras, Richard Berman, David W. Andrews and Qiyin Fang, “High-speed multifocal array scanning using refractive window tilting,” Biomedical Optics Express 6, 3737-3757 (2015). (Open Access)
  • Tianyi Guo, M. Jamal Deen, C-Q, Xu, Qiyin Fang, P. Ravi Selvaganapathy, Haiying Zhang, “Observation of ultraslow stress release in silicon nitride film on CaF2,” J. of Vacuum Science & Technology A, 33, 041515, 2015 (PDF)
  • R. Liu, Z. Zhao, L. Zou, Q. Fang, L. Chen, A. Argento, J. F. Lo, “Compact, non-invasive frequency domain lifetime differentiation of collagens and elastin,” Sensors and Actuators, B: Chemical, 219(8): 289-293, 2015 (PDF)
  • Samir Sahli, Roy, C. C. Wang, Aparna Murthy, David Armstrong, M. Jamal Deen, and Qiyin Fang, “a 360 degree side view endoscope for lower GI tract mapping,” Physics in Canada, 75(1): 18-20, 2015
  • Shu-Chi Allison Yeh, Celine S.N. Ling, David W. Andrews, Michael S. Patterson, Kevin R. Diamond, Joseph E. Hayward, David Armstrong, and Qiyin Fang, “5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett’s Esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015 (PDF).
  • Shu-Chi Allison Yeh, Samir Sahli, David W. Andrews, Michael S. Patterson, David Armstrong, John Provias, and Qiyin Fang, “5-aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models,” Journal of Biomedical Optics, 20(2):028002, 2015 (PDF).
  • Tianyi Guo, Yin Wei, Changqing Xu, Benjamin R. Watts, Zhiyi Zhang, Qiyin Fang, Haiying Zhang, P. Ravi Selvaganapathy, and M. Jamal Deen,”Counting of E. Coli by a Micro-flow Cytometer Based on a Photonic-Microfluidic Integrated Device,” Electrophoresis, 36(2): 298-304, 2015 (PDF).


  • Shu-Chi Allison Yeh, Michael S. Patterson, Joseph E. Hayward, and Qiyin Fang, “Time-resolved fluorescence in photodynamic therapy,” Photonics, 1(4): 530-564 (Open Access)
  • Leo Hsu, P. Ravi Selvaganapathy, J. Brash, Q. Fang, C-Q. Xu, M. Jamal Deen, and Hong Chen, “Development of a low-cost Hemin-based dissolved oxygen sensor with anti-biofouling coating for water monitoring,” IEEE Sensors, 14(10):3400-3407, 2014 (PDF)
  • Vinh Nguyen Du Le, Zhaojun Nie, Joseph E. Hayward, Thomas J. Farrell, and Qiyin Fang, “Measurements of extrinsic fluorescence in Intralipid and polystyrene microspheres,” Biomedical Optics Express, 5(8): 2726-2735 (Open Access)


  • Derek J. Cappon, Thomas J. Farrell, Qiyin Fang, Joseph E. Hayward, “A Novel Fibre Optic Probe Design and Optical Property Recovery Algorithm for Optical Biopsy of Brain Tissue,” Journal of Biomedical Optics 18(10):107004, 2013 (PDF)
  • Zhaojun Nie, Ran An, Joseph E. Hayward, Thomas J. Farrell, Qiyin Fang, “Hyperspectral fluorescence lifetime imaging for optical biopsy,” Journal of Biomedical Optics 18 (9):096001, 2013, doi: 10.1117/1.JBO.18.9.096001, (PDF)
  • Ran An; Ghadeer W. Khadar; Emilia I. Wilk; Brent Emigh; Harold K. Haugen; Gregory R. Wohl; Brett Dunlop; Mehran Anvari; Joseph E. Hayward; Qiyin Fang, “Ultrafast laser ablation and machining large-size structures on porcine bone,” Journal of Biomedical Optics 18 (7):070504, 2013, doi: 10.1117/1.JBO.18.7.070504, (Open Access)


  • Zhiyun Li, M. Jamal Deen, Qiyin Fang, and P. R. Selvaganapathy, “Design of a flat field concave-grating-based micro-Raman spectrometer for environmental applications,” Applied Optics, 51(28):6855-6863, 2012 (PDF).
  • Allison Yeh, Kevin Diamond, Michael Patterson, Zhaojun Nie, Joseph Hayward, Qiyin Fang, “Monitoring Photosensitizer Uptake Using Two Photon Fluorescence Lifetime Imaging Microscopy,” Theranostics; 2(9):817-826, 2012 (Open Access).
  • Brent Emigh, Ran An, Eugene M. Hsu, Travis H. R. Crawford, Harold K. Haugen, Gregory R. Wohl, Joseph E. Hayward, and Qiyin Fang, “Porcine cortical bone ablation by ultrafast pulsed laser irradiation,” Journal of Biomedical Optics, 17(2):028001, 2012 (PDF)
  • Anthony Tsikouras, Jin Ning, Sandy Ng, Rirchard Berman, David W. Andrews, and Qiyin Fang, “Streak camera crosstalk reduction using a multiple delay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012. (PDF)


  • Regina Won Kay Leung, Shu-Chi Allison Yeh, and Qiyin Fang, “Effects of incomplete decay in fluorescence lifetime estimation,” Biomedical Optics Express 2(9):2517–2531, 2011. (PDF)
  • Munir El-Desouki, Ognian Marinov, M. Jamal Deen, Qiyin Fang, “CMOS Active-Pixel Sensor With In-Situ Memory for Ultrahigh-Speed Imaging,” IEEE Sensors Journal, 11(6): 1375-1379, 2011. (PDF)
  • Roy Chih Chung Wang, M. Jamal Deen, David Armstrong, and Qiyin Fang, “development of a catadioptric endoscope objective with forward and side views,” Journal of Biomedical Optics, 16(6):066015, 2011. (PDF)
  • Munir El-Desouki, Darek Palubiak, M. Jamal Deen, Qiyin Fang, Ognian Marinov, “A novel, high-dynamic range, high-speed, and high sensitibility CMOS imager using time-domain single-photon counting and avalanche photodiodes,” IEEE Sensors Journal, 11(4): 1078-1083, 2011. (PDF)


  • P. V. Butte, Q. Fang, J. A. Jo, W. H. Yong, B. K. Pikul, K. L. Black, and L. Marcu, Intraoperative delineation of primary brain tumors using time-resolved fluorescence spectroscopy,” Journal of Biomedical Optics, 15: 027008, 2010 (PDF)
  • J. F. Lo, P. Butte, Q. Fang, S. J. Chen, T. Papaioannou, E. S. Kim, M. Gundersen, L. Marcu, “Multilayered MOEMS tunable spectrometer for fluorescence lifetime detection,” IEEE Photonics Technology Letters, 20(7):486-488, 2010. (PDF)


  • Y. Yuan, J-Y. Hwang, M. Krishnamoorthy, J. Ning, Y. Zhang, K. Ye, R. C. Wang, M. J. Deen, Q. Fang, “A high throughput AOTF-based time-resolved fluorescence spectrometer for optical biopsy,” Optics Letters, 34(7): 1132-1134, 2009. (PDF)
  • L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J-H. Qiao, J. D. Baker, J. A. Freischlag, M. C. Fishbein, “Detection of Rupture-Prone Atherosclerotic Plaques by Time-Resolved Laser Induced Fluorescence Spectroscopy,” Atherosclerosis, Vol. 204(1): 156-164, 2009. (PDF)
  • Joe Lo, Shi-Jui Chen, Qiyin Fang, Thanassis Papaioannou, Eun-Sok Kim, Martin Gundersen and Laura Marcu, “Performance of Diaphragmed Microlens for a Packaged Microspectrometer,” Sensors, 9: 859-868, 2009 (PDF)
  • Munir El-Desouki, M. Jamal Deen, Qiyin Fang, Louis W. C. Liu, Frances Tse and David Armstrong, “CMOS Image Sensors for High Speed Applications,” Sensors, 9: 430-444, 2009. (PDF)
  • N. Faramarzpour, M. M. El-Desouki, M. J. Deen, S. Shirani, Q. Fang, “CMOS photodetector systems for low-level light applications,” Journal of Material Sciences: Materials in Electronics, invited, 20(S1): 87-93, 2009. (PDF)


  • Ye Yuan, Thanassis Papaioannou, Qiyin Fang, “Single shot acquisition of time-resolved fluorescence spectra using a multiple delay optical fiber bundle,” Optics Letters, 33(8): 791-793, 2008. (PDF)
  • N. Faramarzpour, M. J. Deen, S. Shirani and Q. Fang, “Fully Integrated Single Photon Avalanche Diode Detector in Standard CMOS 0.18μm Technology,” IEEE Transactions on Electron Devices, Vol. 55(3): 760-767, 2008. (PDF)
  • J. A. Russell, K. R. Diamond, T. Collins, H. F. Tiedje, J. E. Hayward, T. J. Farrell, M. S. Patterson, Q. Fang, “Characterization of Fluorescence Lifetime of Photofrin and Delta-Aminolevulinic Acid Induced Protoporphyrin IX in Living Cells using Single and Two-photon Excitation,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 158-166, 2008. (PDF)
  • M. Kfouri, O. Marinov, P. Quevedo, N. Faramarzpour, S. Shirani, L. W-C. Liu, Q. Fang, M. J. Deen, “Towards a Miniaturized Wireless Fluorescence-Based Diagnostic Imaging System,” IEEE Journal of Se-lected Topics in Quantum Electronics, 14(1): 226-234, 2008. (PDF)
  • N. Faramarzpour, M. M. El-Desouki, M. J. Deen, Q. Fang, S. Shrani and L. W-C. Liu, “CMOS Imaging for Biomedical Applications,” IEEE Potentials, May/June: 31-36, 2008. (PDF)


  • N. Faramarzpour, M. J. Deen, S. Shirani, Q. Fang, L. W. C. Liu, F. Campos, and J. W. Swart, “CMOS based active pixel for low-light-level detection: analysis and measurements,” IEEE Transactions on Elec-tron Devices, 54(12): 3229-3237, 2007. (PDF)
  • J. A. Jo, L. Marcu, Q. Fang, T. Papaioannou, J. H. Qiao, M. C. Fishbein, B. Beseth, A. H. Dorafshar, T. Reil, D. Baker, J. Freischlag, “New Methods for Time-resolved Fluorescence Spectroscopy Data Analysis Based on the Laguerre Expansion Technique Applications in Tissue Diagnosis,” Methods of Information in Medicine, Vol. 46(2): 206-211, 2007. (PDF)
  • J. F. Lo, Q. Fang, L. Marcu and E. S. Kim, “Wafer-level packaging of three-dimensional MOEMS device with lens diaphragm,” IEEE International Conference on Micro-Electrical-Mechanical Systems (MEMS), Jan. 21-25, 2007, Japan. (PDF)


  • J. A. Jo, Q. Fang, T. Papaioannou, J. D. Baker, A. H. Dorafshar, T. Reil, J. H. Qiao, M. C. Fishbein, J. A. Freischlag, L. Marcu; “Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions,” Journal of Biomedical Optics, Vol. 11 (2): 021004, 2006 (PDF)
  • W. H. Yong, P. V. Butte, B. K. Pikul, J. A. Jo, Q. Fang, T. Papaioannou, K. L. Black, and L. Marcu, “Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy,” Frontiers in Biosciences, Vol. 11: 1255-1263, 2006. (PDF)


  • J. A. Jo, Q. Fang, L. Marcu, “Ultrafast method for the analysis of fluorescence lifetime imaging microscopy data based on the Laguerre expansion technique,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 11(4): 835-845, 2005. (PDF)
  • L. Marcu, Q. Fang, J. A. Jo, T. Papaioannou, A. Dorafshar, T. Reil, J.H. Qiao, D. Baker, J. A. Freischlag M. C. Fishbein,. In-Vivo Detection of Macrophages in a Rabbit Atherosclerotic Model by Time-Resolved Laser-Induced Fluorescence Spectroscopy. Atherosclerosis, Vol. 181(2): 295-303, 2005. (PDF)


  • Q. Fang, T. Papaioannou, J. Jo, R. Vaitha, K. Shastry, and L. Marcu, “Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics,” Review of Scientific Instrument, Vol. 75(1): 151-162, 2004. (PDF)
  • Q. Fang and X. H. Hu, “Modeling of skin-tissue ablation by nanoseconds laser pulses from ultra violet to near-inferred and comparison with experimental results,” IEEE Journal of Quantum Electronics, Vol.40(1): 69-77, 2004. (PDF)
  • J. A. Jo, Q. Fang, T. Papaioannou, and L. Marcu, “Fast model-free deconvolution of fluorescence decay for analysis of biological systems,” Journal of Biomedical Optics, Vol. 9(4):743-752, 2004. (PDF)
  • T. Papaioannou, N. Preyer, Q. Fang, M. Carnohan, R. Ross, A. Brightwell, G. Cottone, L. Jones, and L. Marcu, “Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm,” Applied Optics, Vol. 43(14): 2846-2860, 2004. (PDF)

Current Regular Schedule (Winter 2017)

Time Monday Tuesday Wednesday Thursday Friday
8:30 - 9:30
9:30 - 10:30 4I03
10:30 - 11:30 4I03 4I03
11:30 - 12:30
12:30 - 13:30
13:30 - 14:30
14:30 - 15:30
15:30 - 16:30
16:30 - 17:30
17:30 - 18:30

Safety Training

Base CoursesAdditional Courses
WHMIS 2012/2015 Laser Safety 2009
Fire Safety 2007/2015 Chemical handling & spills 2007
Asbestos Awareness 2007 Due Diligence 2006/2013
Ergonomics 2007 Lock out Tag out 2008
Slips/Trips/Falls 2007 Basic Electrical 2008
Eng. Phys. Safety 2007 Eng Phys Laser Safety 2006
Biosafety 2 2012/2015
Biosafety supervisor 2016
TDGR 2013

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