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group_4_presentation_1_-_post-traumatic_stress_disorder [2017/10/05 11:46] tenhovj [Origin & Background] |
group_4_presentation_1_-_post-traumatic_stress_disorder [2018/01/25 15:18] (current) |
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| === Neurobiology of Serotonin === | === Neurobiology of Serotonin === | ||
| - | In the brain, specifically in the brainstem medical and dorsal raphe nuclei, serotonin cell bodies (5-HT) regulate important functions (Kelmendi et al., 2016). Some vital roles that the 5-HT regulates include sleep, motor function, cognition and aggression (Sherin & Nemeroff, 2011). Previous research indicated that 5-HT is involved in stress response in patients with PTSD since the 5-HT neurons mediate anxiety producing effects on individuals through the 5-HT2 receptors (Sherin & Nemeroff, 2011). On the other hand, the 5-HT1A receptors regulate anti-anxiety producing effects from the median raphe. The5-HT1A and 5-HT1B receptors have been associated with disorders including PTSD (Bailey et al., 2013). Any changes in the functional 5-HT pathway may contribute to intrusive memories and impulsivity that is associated with PTSD symptoms PTSD (Bailey et al., 2013). Furthermore, Sari identifies the 5-HT1B receptor to be associated with PTSD. In the study, when there was a reduced amount of 5-HT1B receptor in the brain, the animals showed anxiety like behaviour (Sari, 2004). | + | In the brain, specifically in the brainstem medical and dorsal raphe nuclei, serotonin cell bodies (5-HT) regulate important functions (Kelmendi et al., 2016). Some vital roles that the 5-HT regulates include sleep, motor function, cognition and aggression (Sherin & Nemeroff, 2011). Previous research indicated that 5-HT is involved in stress response in patients with PTSD since the 5-HT neurons mediate anxiety producing effects on individuals through the 5-HT2 receptors (Sherin & Nemeroff, 2011). On the other hand, the 5-HT1A receptors regulate anti-anxiety producing effects from the median raphe. The 5-HT1A and 5-HT1B receptors have been associated with disorders including PTSD (Bailey et al., 2013). Any changes in the functional 5-HT pathway may contribute to intrusive memories and impulsivity that is associated with PTSD symptoms(Bailey et al., 2013). Furthermore, Sari identified that the 5-HT1B receptor to be associated with PTSD, when there was a reduced amount of 5-HT1B receptor, the animals showed anxiety like behaviour (Sari, 2004). |
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