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group_2_presentation_3_-_herpes_simplex_virus [2018/03/30 19:49] yousifcr |
group_2_presentation_3_-_herpes_simplex_virus [2018/03/30 19:59] (current) babadim [Transmission of HSV-1] |
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| + | {{:herpes_simplex_virus_group_2.pdf|}} | ||
| ====== Herpes Simplex Virus ====== | ====== Herpes Simplex Virus ====== | ||
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| ====== Transmission of HSV-1 ====== | ====== Transmission of HSV-1 ====== | ||
| - | <box 20% round right| >{{ :herpes.jpg?200|}}</box|Figure 4: An individual exhibiting a cold sore caused by HSV-1. (IN TEXT)> | + | <box 20% round right| >{{ :herpes.jpg?200|}}</box|Figure 4: An individual exhibiting a cold sore caused by HSV-1. https://skinpractice.com/best-product-reviews-for-cold-sores/> |
| Initial infection with HSV-1 is caused by contact with mucosal surfaces or abraded skin (Whitley & Roizman, 2001) in regions such as the lips, mouth, and skin above the waist (Nahmias, Keyserling & Lee, 1989). An individual can be affected with HSV-1 through close nonsexual contact with an affected individual such as kissing (even on the cheek), sharing utensils and sharing drinks, as the virus can remain viable for a brief period of time on skin, clothing and plastics (Fatahzadeh & Schwartz, 2007). An individual is most contagious when they are exhibiting cold sores or lesions, but is still contagious without showing symptoms. | Initial infection with HSV-1 is caused by contact with mucosal surfaces or abraded skin (Whitley & Roizman, 2001) in regions such as the lips, mouth, and skin above the waist (Nahmias, Keyserling & Lee, 1989). An individual can be affected with HSV-1 through close nonsexual contact with an affected individual such as kissing (even on the cheek), sharing utensils and sharing drinks, as the virus can remain viable for a brief period of time on skin, clothing and plastics (Fatahzadeh & Schwartz, 2007). An individual is most contagious when they are exhibiting cold sores or lesions, but is still contagious without showing symptoms. | ||
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| Whether or not the virus using endocytosis or fusion at the plasma membrane is dependent upon individual cell types that they encounter. In Vero and Hep2 infected cells, there is no preference. However, in CHO, HeLa, RPE, human epidermal keratinocytes and KCjE cells, there is a preference for endocytosis. (Akhtar & Shukla, 2009) | Whether or not the virus using endocytosis or fusion at the plasma membrane is dependent upon individual cell types that they encounter. In Vero and Hep2 infected cells, there is no preference. However, in CHO, HeLa, RPE, human epidermal keratinocytes and KCjE cells, there is a preference for endocytosis. (Akhtar & Shukla, 2009) | ||
| - | <box 55% round| >{{ :complex.png?500|}} </box| Figure 9: The molecular interactions that facilitate HSV entry (Akhtar & Shukla, 2009)> | + | <box 45% round| >{{ :complex.png?500|}} </box| Figure 9: The molecular interactions that facilitate HSV entry (Akhtar & Shukla, 2009)> |
| ====== Post Entry Into Host Cell for HSV-1 & HSV-2 ====== | ====== Post Entry Into Host Cell for HSV-1 & HSV-2 ====== | ||
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| ====== Neural Cells Affected by HSV-2 ====== | ====== Neural Cells Affected by HSV-2 ====== | ||
| - | <box 35% round right| >{{ :sacral.png?300|}} | + | <box 30% round right| >{{ :sacral.png?300|}} |
| </box| Figure 11: Distribution of the sacral nerve ganglia. (Vassantachart, & Menter, 2016)> | </box| Figure 11: Distribution of the sacral nerve ganglia. (Vassantachart, & Menter, 2016)> | ||
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| <box 20% round left| >{{ :acyclovir.jpg?200|}}</box|Figure 12: Acyclovir Medication for treatment of Herpes Simplex Virus. Brand names include Avirax, and Zovirax (Jane, 2011).> | <box 20% round left| >{{ :acyclovir.jpg?200|}}</box|Figure 12: Acyclovir Medication for treatment of Herpes Simplex Virus. Brand names include Avirax, and Zovirax (Jane, 2011).> | ||
| - | <box 35% round left| >{{ :valacyclovir-hcl.jpg?400|}}</box|Figure 13: Valacyclovir HCl Medication, used for the treatment of Cold Sores (Oral Herpes) and Genital Herpes, as well as Shingles (HSVType 1, 2013).> | + | <box 35% round left| >{{ :valacyclovir-hcl.jpg?380|}}</box|Figure 13: Valacyclovir HCl Medication, used for the treatment of Cold Sores (Oral Herpes) and Genital Herpes, as well as Shingles (HSVType 1, 2013).> |
| <box 30% round left| >{{ :famciclovir.jpg?300|}}</box|Figure 14: Famciclovir Medication is also another treatment option for Genital Herpes, and Shingles (Doktor, 2018).> | <box 30% round left| >{{ :famciclovir.jpg?300|}}</box|Figure 14: Famciclovir Medication is also another treatment option for Genital Herpes, and Shingles (Doktor, 2018).> | ||
