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Introduction

Etiology

The Ebola virus was first identified in 1976, localized near the Ebola river, primarily in the Democratic Republic of Congo and Sudan (CDC). The virus is known to affect both humans and non-human primates, including chimpanzees, gorillas, and orangutangs. Moreover, there are 5 known strains of the Ebola virus, with the most common among humans being the Zaire virus. In addition, the Reston virus has been found to propagate disease in nonhuman primates but not among human populations (CDC).

Ebola Strains/ Variants:

  • Zaire ebolavirus
  • Sudan ebolavirus
  • Taï Forest ebolavirus
  • Bundibugyo ebolavirus
  • Reston ebolavirus

Epidemiology: Ebola Outbreak (2013-2016)

Essentially, recurrent epileptic seizures may range in severity from benign episodes to life-threatening or disabling instances. In general, epileptic seizures are caused by an interference in the regular neuronal patterning, resulting in abnormal sensations and behaviours, including convulsions, twitching, muscle spasticity, and a loss of consciousness. Moreover, epilepsy may be attributable to an abnormality in brain circuitry, nerve signaling imbalances, deviant neurotransmitter concentrations, and abnormalities of gated ion channels integral to neuronal signaling. (PUBMED HEALTH) (Bromfield et al., 2006)

The causes of epileptic seizures can be attributable to several inducing factors, namely:

  • 1. Idopathic cause (spontaneous/ unknown cause): assumed to have genetic basis, however, no gross anatomical or pathological abnormality evident. General onset is during childhood, and seen in in over 50% of all cases of epilepsies.
  • 2. Symptomatic cause: identified brain insult is the cause, tumor, infection, head injury, lack of oxygen (at birth), stroke. Seizures may occur due to developmental disorders or malformations or which progress due to changes in response to an insult or injury
  • 3. Cryptogenic: obscure or uncertain cause (more than half of cases)

(Shorvon, 2011)

Several risk factors have been suggested causative agents for epilepsy, namely in disrupting the normal neuronal signaling patterns of the CNS. Some of these risk factors include:

  • Age: most common during early childhood and after the age of 60, however can occur at any age
  • Family history of epilepsy
  • Head injury
  • Stroke
  • Brain infections: bacterial/viral meningitis, cerebral malaria, etc.

Symptoms and Stages of Ebola

There are 4 distinguishable stages of the Ebola virus and symptoms tend to arise 2-21 days following exposure to the disease via contaminated bodily fluids in most cases. It is usual for symptoms to occur between 8-10 days after contraction of the virus.

*Stage 1*: Lasts from a period of 1-9 days following exposure to the virus. Symptoms that identify this stage include joint pain, sore throat, fever, headache, weakness, and muscle soreness

*Stage 2*: Begins on approximately the 10th day of infection and is characterized by vomiting blood, diarrhea, high fever, and extreme fatigue.

*Stage 3*: Begins on the 11th day following transmission of the disease and is characterized by brain damage, bleeding from the nose, mouth, and anus. During this period, it is common for bodily fluids to contaminate living environments, resulting in a higher risk of transmission among humans.

*Stage 4*: Begins on approximately the 12th day following infection by the virus and is characterized by the occurrence of a coma, organ failure, shock, severe internal bleeding, and in cases where no immediate treatment or hospitalization is sought out, death may occur.

Transmission

Diagnosis

Pathophysiology of Ebola

Treatments

References

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