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group_2_presentation_2_-_migraines [2016/03/05 15:02]
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group_2_presentation_2_-_migraines [2018/01/25 15:18] (current)
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 ====== Migraines ====== ====== Migraines ======
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 Migraines are one of the oldest documented illness being described as early as 1200 BCE by the Egyptians. Arataeus of Cappadocia is however the one credited with the discovery of migraines after having extensively described unilateral headaches with aura. Migraines have plagued humans throughout our history with little progress made in the area of treatment and cures. Several treatments have been tried with no avail, including hot irons, bloodletting,​ inserting garlic into incisions made in the temple and applying opium and vinegar solutions directly to the skull. Some have even gone as far as to perform surgeries such as lobotomies on migraine sufferers. Trepanation involves making a hole in the skull to let out evil spirits that presumably were causing the migraine. It is possibly the oldest surgery in history and may date as far back as 6500 BCE.  Migraines are one of the oldest documented illness being described as early as 1200 BCE by the Egyptians. Arataeus of Cappadocia is however the one credited with the discovery of migraines after having extensively described unilateral headaches with aura. Migraines have plagued humans throughout our history with little progress made in the area of treatment and cures. Several treatments have been tried with no avail, including hot irons, bloodletting,​ inserting garlic into incisions made in the temple and applying opium and vinegar solutions directly to the skull. Some have even gone as far as to perform surgeries such as lobotomies on migraine sufferers. Trepanation involves making a hole in the skull to let out evil spirits that presumably were causing the migraine. It is possibly the oldest surgery in history and may date as far back as 6500 BCE. 
-The first known use of medication that has shown some success is use of ergotamine in the 1930s. Ergotamine constricts blood vessels in the brain and has been shown to provide pain relief in some individuals. Many drugs have been researched and experimented with since with little success. The first and currently only class of drugs developed and used solely for the treatment of migraines are Triptans, which were developed in the early 1990s. ​+The first known use of medication that has shown some success is use of ergotamine in the 1930s. Ergotamine constricts blood vessels in the brain and has been shown to provide pain relief in some individuals. Many drugs have been researched and experimented with since with little success. The first and currently only class of drugs developed and used solely for the treatment of migraines are Triptans, which were developed in the early 1990s (American Migraine Foundation, 2016)
  
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-**Family History:** Upto 90% of people who suffer from migraines have family members who have had the same condition. If one or both of your parents have migraines, then there is a good chance that you would suffer from migraine attacks.+**Family History:** Upto 90% of people who suffer from migraines have family members who have had the same condition. If one or both of your parents have migraines, then there is a good chance that you would suffer from migraine attacks ​(Mayo Clinic, 2013).
  
  
  
-**Age:** One can develop migraines at any age, but most people who suffer from migraine attacks get their first attack during adolescence. By age 40, most people who suffer from migraines would got their first migraine attack. ​+**Age:** One can develop migraines at any age, but most people who suffer from migraine attacks get their first attack during adolescence. By age 40, most people who suffer from migraines would got their first migraine attack ​(Mayo Clinic, 2013)
  
  
  
-**Sex:** Women are 3 times more likely to suffer from migraine attacks than men. Boys tend to get more headaches than girls during childhood, but during and after puberty, girls suffer from migraines overwhelmingly more than boys.+**Sex:** Women are 3 times more likely to suffer from migraine attacks than men. Boys tend to get more headaches than girls during childhood, but during and after puberty, girls suffer from migraines overwhelmingly more than boys (Mayo Clinic, 2013).
  
  
  
-**Hormonal changes:** Women are more susceptible to migraines during the onset or immediately after menstruation. ​+**Hormonal changes:** Women are more susceptible to migraines during the onset or immediately after menstruation ​(Mayo Clinic, 2013).
  
  
  
-**Genetics:​** mutations in a number of difference genes have been implicated in migraines. These genetic changes tend to lead to channelopathies that make the neurovascular system hyperexcitable ​+**Genetics:​** mutations in a number of difference genes have been implicated in migraines. These genetic changes tend to lead to channelopathies that make the neurovascular system hyperexcitable ​(Mayo Clinic, 2013).
  
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-The pathophysiology of migraine is fairly well understood, and evidence supports contributory roles of both neural and vascular mechanisms. It is a multifactorial disease whose progression is a result of the interaction of genes and environment. Researchers have identified a linkage to chromosome 19 and the biological basis for this is mutations involving the Cav2.1 (P/Q) type voltage-gated calcium channel CACNA1A gene. Now known as FHM-I, this mutation is responsible for about 50% of the identified families with familial hemiplegic migraine. One consequence of this mutation may be enhanced glutamate release. Researchers also indicate the possibility of a deficiency in serotonin levels however, the mechanism behind this is not well understood. Migraine genes give individuals a predisposition for developing migraine headaches but other factors like stress, food triggers, environmental triggers, hormonal changes or sleep disturbances are necessary triggers. The manifestation of headache in migraineurs is due to the activation of the trigeminovascular system, which is the major pain signaling system in the brain, followed by the release of vasodilatory neuropeptides. Changes in circulating levels of the neurotransmitter serotonin (5-HT) are characteristic of migraine and may contribute to the pathogenesis of the disorder. Recent progress in understanding the pathophysiology of migraine includes the identification of the physiologic roles of vasoactive neuropeptides associated with migraine and the characterization of 5-HT receptor subtypes.+The pathophysiology of migraine is fairly well understood, and evidence supports contributory roles of both neural and vascular mechanisms. It is a multifactorial disease whose progression is a result of the interaction of genes and environment. Researchers have identified a linkage to chromosome 19 and the biological basis for this is mutations involving the Cav2.1 (P/Q) type voltage-gated calcium channel CACNA1A gene (Noseda & Burstein, 2013). Now known as FHM-I, this mutation is responsible for about 50% of the identified families with familial hemiplegic migraine ​(Noseda & Burstein, 2013). One consequence of this mutation may be enhanced glutamate release. Researchers also indicate the possibility of a deficiency in serotonin levels however, the mechanism behind this is not well understood. Migraine genes give individuals a predisposition for developing migraine headaches but other factors like stress, food triggers, environmental triggers, hormonal changes or sleep disturbances are necessary triggers. The manifestation of headache in migraineurs is due to the activation of the trigeminovascular system, which is the major pain signaling system in the brain, followed by the release of vasodilatory neuropeptides ​(Noseda & Burstein, 2013). Changes in circulating levels of the neurotransmitter serotonin (5-HT) are characteristic of migraine and may contribute to the pathogenesis of the disorder. Recent progress in understanding the pathophysiology of migraine includes the identification of the physiologic roles of vasoactive neuropeptides associated with migraine and the characterization of 5-HT receptor subtypes.
  
  
-It is thought that the migraine begins with this reversible, transient cortical event known as cortical spreading depression (CSD). It is a slow moving wave of depolarization that starts in the occipital lobe and moves forward and is followed by a prolonged inhibition of cortical activity. First identified by Leão in the rabbit, this distinctive electrophysiological phenomenon has been correlated with the visual aura that precedes the onset of headache in migraine. Although it is not clear how CSD begins in the human brain, genetic factors are likely to play a role in individual CSD susceptibility. The current understanding of the genetic factors underlying migraine and CSD comes from studies of rare monogenic mutations in patients diagnosed with the common form of familial hemiplegic migraine (FHM). In agreement with the human data, mice carrying FHM mutations have shown increased susceptibility to CSD and altered synaptic transmission. That cortical excitability is also evident in psychophysical and neurophysiological studies that demonstrate abnormal processing of sensory information even between attacks. Such altered excitability may also contribute to typical migraine with aura, as suggested by a genetic mutation in a two-pore domain potassium channels that regulate neuronal resting potential and excitability. Together, these findings support the notion that neuronal excitability plays a pivotal role in the predisposition to develop a migraine. ​+It is thought that the migraine begins with this reversible, transient cortical event known as cortical spreading depression (CSD). It is a slow moving wave of depolarization that starts in the occipital lobe and moves forward and is followed by a prolonged inhibition of cortical activity ​(Noseda & Burstein, 2013). First identified by Leão in the rabbit, this distinctive electrophysiological phenomenon has been correlated with the visual aura that precedes the onset of headache in migraine ​(Noseda & Burstein, 2013). Although it is not clear how CSD begins in the human brain, genetic factors are likely to play a role in individual CSD susceptibility. The current understanding of the genetic factors underlying migraine and CSD comes from studies of rare monogenic mutations in patients diagnosed with the common form of familial hemiplegic migraine (FHM). In agreement with the human data, mice carrying FHM mutations have shown increased susceptibility to CSD and altered synaptic transmission ​(Noseda & Burstein, 2013). That cortical excitability is also evident in psychophysical and neurophysiological studies that demonstrate abnormal processing of sensory information even between attacks. Such altered excitability may also contribute to typical migraine with aura, as suggested by a genetic mutation in a two-pore domain potassium channels that regulate neuronal resting potential and excitability ​(Noseda & Burstein, 2013). Together, these findings support the notion that neuronal excitability plays a pivotal role in the predisposition to develop a migraine. ​
  
  
  
-This cortical spreading depression is what initiates the activation of the trigeminovascular system. It begins through antidromic activation at distal trigeminal nerve terminals, which release neurotransmitters including substance P, neurokinin A and calcitonin gene related peptide (CGRP). Calcitonin gene-related peptide is the most potent vasodilator neurotransmitter of the trigeminal system. Substance P, a nondecapeptide involved in nociceptive transmission has vasodilatory effects on the cerebrum. Neurokinin A is a decapeptide with a profile of action and localization in the trigeminal system that is similar to that of substance P but with less potent vasodilatory effects and longer-lasting effects on blood vessel permeability. The critical neuropeptide in the generation of migraine seems to be CGRP rather than substance P or neurokinin A. These substances then bind to receptors on intracranial blood vessels and cause vasodilation,​ plasma protein extravasation and ultimately sterile inflammation. This results in the reactivation of the trigeminal nerve but now in an orthodromic fashion. The signal is relayed to the trigeminal nucleus caudalis which is a central structure in the brain stem that forwards pain impulses to the thalamus and ultimately the sensory cortex. This atypical, stimulus induced activation of the brain stem during and between migraine attacks, leads to the lack of normal habituation to repetitive stimuli and ultimately sensitization. Sensitization is the idea that repeated administration of a stimulus results in progressive amplification of a response. Once the first order trigeminal neurons become sensitized, normally innocuous, intracranial stimuli, such as a pulsating artery, become painful and result in a throbbing pain made worse with activity. If the pain is unsuccessfully treated, second order and third order neurons extending through the midbrain, thalamus and cortex are continuously activated. This can ultimately lead to central sensitization caused by pain from stimuli that are normally not painful. ​+This cortical spreading depression is what initiates the activation of the trigeminovascular system. It begins through antidromic activation at distal trigeminal nerve terminals, which release neurotransmitters including substance P, neurokinin A and calcitonin gene related peptide (CGRP (Noseda & Burstein, 2013)). Calcitonin gene-related peptide is the most potent vasodilator neurotransmitter of the trigeminal system. Substance P, a nondecapeptide involved in nociceptive transmission has vasodilatory effects on the cerebrum ​(Noseda & Burstein, 2013). Neurokinin A is a decapeptide with a profile of action and localization in the trigeminal system that is similar to that of substance P but with less potent vasodilatory effects and longer lasting effects on blood vessel permeability ​(Noseda & Burstein, 2013). The critical neuropeptide in the generation of migraine seems to be CGRP rather than substance P or neurokinin A. These substances then bind to receptors on intracranial blood vessels and cause vasodilation,​ plasma protein extravasation and ultimately sterile inflammation ​(Noseda & Burstein, 2013). This results in the reactivation of the trigeminal nerve but now in an orthodromic fashion. The signal is relayed to the trigeminal nucleus caudalis which is a central structure in the brain stem that forwards pain impulses to the thalamus and ultimately the sensory cortex ​(Noseda & Burstein, 2013). This atypical, stimulus induced activation of the brain stem during and between migraine attacks, leads to the lack of normal habituation to repetitive stimuli and ultimately sensitization. Sensitization is the idea that repeated administration of a stimulus results in progressive amplification of a response ​(Noseda & Burstein, 2013). Once the first order trigeminal neurons become sensitized, normally innocuous, intracranial stimuli, such as a pulsating artery, become painful and result in a throbbing pain made worse with activity. If the pain is unsuccessfully treated, second order and third order neurons extending through the midbrain, thalamus and cortex are continuously activated ​(Noseda & Burstein, 2013). This can ultimately lead to central sensitization caused by pain from stimuli that are normally not painful. ​
  
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 ====== Treatment ====== ​ ====== Treatment ====== ​
-To date, there is no actual cure for migraine sufferers. Ideally, acute treatment of migraine should work rapidly, with few side effects, be cost effective and get the patient functional as soon as possible. Drug therapeutics that do exist are primarily targeted around symptom relief during and after the migraine attack. Acute treatment can be divided into migraine specific and nonspecific therapy. ​<​sup>​[12]</​sup>​+To date, there is no actual cure for migraine sufferers. Ideally, acute treatment of migraine should work rapidly, with few side effects, be cost effective and get the patient functional as soon as possible. Drug therapeutics that do exist are primarily targeted around symptom relief during and after the migraine attack. Acute treatment can be divided into migraine specific and nonspecific therapy.
  
 **Ergotamines:​**  ​ **Ergotamines:​**  ​
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-It was first isolated by Arthur Stole in 1918 and first used as a treatment option for migraines in 1925. Its chemical structure is similar to that of amines, serotonin, norepinephrine and dopamine. The mode of action of ergotamine in migraine may be by means of selective arterial vasoconstriction on certain cranial vessel beds or, alternatively,​ by depression of central serotonergic neurons mediating pain transmission or circulatory regulation. They have a complex mode of action that involves interaction with a variety of receptors which include 5-HT, dopamine and noradrenaline. ​ +It was first isolated by Arthur Stole in 1918 and first used as a treatment option for migraines in 1925 (Kalra & Elliott, 2007). Its chemical structure is similar to that of amines, serotonin, norepinephrine and dopamine. The mode of action of ergotamine in migraine may be by means of selective arterial vasoconstriction on certain cranial vessel beds or, alternatively,​ by depression of central serotonergic neurons mediating pain transmission or circulatory regulation ​(Kalra & Elliott, 2007). They have a complex mode of action that involves interaction with a variety of receptors which include 5-HT, dopamine and noradrenaline. ​
  
  
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-1.Activation of  5-HT1B receptors located on intracranial blood vessels, leads to vasoconstriction of blood vessels+1.Activation of  5-HT1B receptors located on intracranial blood vessels, leads to vasoconstriction of blood vessels ​(Kalra & Elliott, 2007).
  
  
  
-2.Activation of 5-HT1D receptors on sensory nerve endings of trigeminal system, inhibits pro-inflammatory neuropeptide release ​ +2.Activation of 5-HT1D receptors on sensory nerve endings of trigeminal system, inhibits pro-inflammatory neuropeptide release ​(Kalra & Elliott, 2007).
  
  
-Oral absorption of ergotamine is about 60-70% and the concurrent administration of caffeine improves both the rate and extent of absorption. Due to high first-pass metabolism, ergotamine has a very low bioavailability from oral administration. Ergotamine and ergotamine-caffeine combination pills still play a role in the acute treatment of migraine in those patients who do not respond adequately to triptan therapy. Ergotamine has more side effects (nausea, vomiting, peripheral and coronary vasoconstriction) due to its relatively nonselective adherence to serotonin, dopamine and adrenergic receptors. ​+Oral absorption of ergotamine is about 60-70% and the concurrent administration of caffeine improves both the rate and extent of absorption ​(Tfelt-hansen et al, 2000). Due to high first-pass metabolism, ergotamine has a very low bioavailability from oral administration ​(Tfelt-hansen et al, 2000). Ergotamine and ergotamine-caffeine combination pills still play a role in the acute treatment of migraine in those patients who do not respond adequately to triptan therapy. Ergotamine has more side effects (nausea, vomiting, peripheral and coronary vasoconstriction) due to its relatively nonselective adherence to serotonin, dopamine and adrenergic receptors ​(Tfelt-hansen et al, 2000)
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-Nausea and vomiting: All ergotamine trials evaluated had some analysis of nausea and/or vomiting. In the four trials where efficacy assessments were made, nausea and/or vomiting either increased in severity after treatment with ergotamine, and more patients were affected than was observed with placebo or there was little difference between the two treatments (10, 12, 14, 15). In all trials where the symptoms were assessed as side effects, more patients were affected following ergotamine than following placebo (9, 10, 12, 13). +Nausea and vomiting: All ergotamine trials evaluated had some analysis of nausea and/or vomiting. In the four trials where efficacy assessments were made, nausea and/or vomiting either increased in severity after treatment with ergotamine, and more patients were affected than was observed with placebo or there was little difference between the two treatments (10, 12, 14, 15). In all trials where the symptoms were assessed as side effects, more patients were affected following ergotamine than following placebo (9, 10, 12, 13) (Dahlof, 1993).
  
  
  
-Global evaluation of medication: Five of the ergotamine trials evaluated presented results for patients’ preference for ergotamine or placebo. In four trials, significantly more patients preferred ergotamine to placebo (10, 12, 13, 15). In the fifth trial, similar numbers of patients clinically diagnosed as having migraine preferred placebo to ergotamine as preferred ergotamine to placebo (13). +Global evaluation of medication: Five of the ergotamine trials evaluated presented results for patients’ preference for ergotamine or placebo. In four trials, significantly more patients preferred ergotamine to placebo (10, 12, 13, 15). In the fifth trial, similar numbers of patients clinically diagnosed as having migraine preferred placebo to ergotamine as preferred ergotamine to placebo (13) (Dahlof, 1993).
  
  
  
-Side effects : The side effect profile of ergotamine and placebo was reported in five of the six trials evaluated (9, 10, 12, 13, 15). In all these trials more patients reported side effects with ergotamine than with placebo. Side effects associated with ergotamine included nausea/ vomiting, dizziness/​vertigo,​ drowsiness/​tiredness,​ numbness, nervousness,​ trembling, dyspnoea and dry mouth. ​+Side effects : The side effect profile of ergotamine and placebo was reported in five of the six trials evaluated (9, 10, 12, 13, 15). In all these trials more patients reported side effects with ergotamine than with placebo. Side effects associated with ergotamine included nausea/ vomiting, dizziness/​vertigo,​ drowsiness/​tiredness,​ numbness, nervousness,​ trembling, dyspnoea and dry mouth (Dahlof, 1993)
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 Triptans like Sumatriptan were developed to treat migraines in the early 1990s. They effectively relieve pain and nausea in approximately 75% of people. Triptans are often reserved for use in those with moderate to severe pain and for those who do not respond to analgesics (Johnston, 2010). They are administered as oral tablets, injections, nasal sprays and pills. Side effects include tingling, pain and tightness in the chest or throat, vomiting, dry mouth, flushing, dizziness and fatigue. In rare cases they can lead to cardiac ischemia (Gilmore, 2011). Triptans act in a similar manner as the ergotamines but are more selective and therefore have less side effects. Triptans are selective 5-hydroxytryptamine (5-HT) receptor agonists with high affinity for 5-HT1B and 5-HT1D receptors. These receptors when activated, constrict blood vessels in the brain to provide relief (Bartleson, 2010). Triptans are often avoided in patients who have cardiovascular disease, a history of stroke or have migraines accompanied by neurological problems. Patients should be evaluated for their risk of developing vascular disease before prescription for triptans is given. Triptans are not addictive but when used frequently, such as 10 or more days per month, medication overuse headaches can result. Triptans like Sumatriptan were developed to treat migraines in the early 1990s. They effectively relieve pain and nausea in approximately 75% of people. Triptans are often reserved for use in those with moderate to severe pain and for those who do not respond to analgesics (Johnston, 2010). They are administered as oral tablets, injections, nasal sprays and pills. Side effects include tingling, pain and tightness in the chest or throat, vomiting, dry mouth, flushing, dizziness and fatigue. In rare cases they can lead to cardiac ischemia (Gilmore, 2011). Triptans act in a similar manner as the ergotamines but are more selective and therefore have less side effects. Triptans are selective 5-hydroxytryptamine (5-HT) receptor agonists with high affinity for 5-HT1B and 5-HT1D receptors. These receptors when activated, constrict blood vessels in the brain to provide relief (Bartleson, 2010). Triptans are often avoided in patients who have cardiovascular disease, a history of stroke or have migraines accompanied by neurological problems. Patients should be evaluated for their risk of developing vascular disease before prescription for triptans is given. Triptans are not addictive but when used frequently, such as 10 or more days per month, medication overuse headaches can result.
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 +**Cardiovascular medications in the treatment of migraine**
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 +Researchers do not yet understand how exactly beta blockers prevent migraines. They are traditionally used for cardiology patients to prevent the stimulation of adrenergic receptors responsible for increased cardiac action. For treating migraines it is thought that they act through beta1 adrenoreceptor inhibition of the activation of third order trigeminovascular nociceptive neurons. The beta blockers propranolol (Inderal La, Innopran XL, others), metoprolol tartrate (Lopressor) and timolol (Betimol) have proved effective for preventing migraines. You may not notice improvement in symptoms for several weeks after taking these medications. However, the usage of beta blockers are not advised if you are over 60, have heart or blood vessel conditions or use tobacco.
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 +Another class of cardiovascular medications (calcium channel blockers) used to treat high blood pressure and keep blood vessels from becoming narrow or wide, also may be helpful in preventing migraines and relieving symptoms of an attack. The use of calcium channel blockers comes from the idea that migraine may be due to a mutation in calcium channels that make them hyperexcitable and as such this medication can help to counteract this effect. Verapamil (Calan, Verelan, others) is a calcium channel blocker that may help you.
  
 **Analgesics** **Analgesics**
  
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-Most first line treatments for migraines are analgesics. Generally, these treatments are used as a primary option in severe cases, and are used when the symptoms of a migraine have just manifested themselves, as to prevent further progression. Analgesics are classified as a non-specific treatment when used in the treatment of migraines, as they are used in the treatment of other conditions as well. As such, they are often used in combination with migraine specific therapies. Common analgesics for migraines are usually a class of drug known as Non-steroidal Anti-inflammatory Drugs (NSAIDS) such as Aspirin and Aleve. NSAIDS are generally used for moderate to severe migraines and are the final non specific treatment for migraines, as they treat the symptoms of migraines, rather than the underlying cause. ​+Most first line treatments for migraines are analgesics. Generally, these treatments are used as a primary option in severe cases, and are used when the symptoms of a migraine have just manifested themselves, as to prevent further progression. Analgesics are classified as a non-specific treatment when used in the treatment of migraines, as they are used in the treatment of other conditions as well (Pfaffenrath,​ 1995). As such, they are often used in combination with migraine specific therapies. Common analgesics for migraines are usually a class of drug known as Non-steroidal Anti-inflammatory Drugs (NSAIDS) such as Aspirin and Aleve. NSAIDS are generally used for moderate to severe migraines and are the final non specific treatment for migraines, as they treat the symptoms of migraines, rather than the underlying cause (Pfaffenrath,​ 1995)
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-NSAIDs work by inhibiting the production of prostaglandins,​ which are the chemical messengers that initiate the pain and inflammation response. Tissue in the human body produces prostaglandins in response to damage, and prostaglandins increase sensitivity in the nerves that send the pain response to the brain, thus establishing the pain threshold. The mechanism by which NSAIDs prevent prostaglandin synthesis is by the inhibition of the cyclooxygenase (COX) enzymes that are found in their metabolic pathway [Figure 6]. There are two classes of COX enzymes, and most traditional NSAIDs that are used to treat migraines inhibit both COX-1 and COX-2. ​ COX-1 is constitutive,​ while COX-2 is induced by injury. The reduction of prostaglandins inhibits pain signaling to the brain, ergo aiding in migraine management.+NSAIDs work by inhibiting the production of prostaglandins,​ which are the chemical messengers that initiate the pain and inflammation response ​(Whalen, K., 2012). Tissue in the human body produces prostaglandins in response to damage, and prostaglandins increase sensitivity in the nerves that send the pain response to the brain, thus establishing the pain threshold ​(Whalen, K., 2012). The mechanism by which NSAIDs prevent prostaglandin synthesis is by the inhibition of the cyclooxygenase (COX) enzymes that are found in their metabolic pathway [Figure 6] (European Neurological Review, 2011). There are two classes of COX enzymes, and most traditional NSAIDs that are used to treat migraines inhibit both COX-1 and COX-2. ​ COX-1 is constitutive,​ while COX-2 is induced by injury ​(European Neurological Review, 2011). The reduction of prostaglandins inhibits pain signaling to the brain, ergo aiding in migraine management.
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 Effectiveness of NSAIDs in the treatment of symptoms: ​ Effectiveness of NSAIDs in the treatment of symptoms: ​
-Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study. The initial dose of naproxen sodium was 825 mg followed one hour later by a further 550 mg, if symptoms were the same or had improved. Patients were seen at admission and then at monthly intervals until a total of ten attacks had been studied. During each attack the patient graded the severity of headache, visual disturbance,​ nausea and other important symptoms (specific to the patient) as none, mild, moderate or severe. In Figure 7, Naproxen sodium produced statistically significantly superior relief of headache in comparison with placebo (p= 0.004) and the duration of headache was significantly shorter in this group than in the placebo group (p= 0.019). Patients in the +Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study (Johnson et. al, 1985). The initial dose of naproxen sodium was 825 mg followed one hour later by a further 550 mg, if symptoms were the same or had improved ​(Johnson et. al, 1985). Patients were seen at admission and then at monthly intervals until a total of ten attacks had been studied. During each attack the patient graded the severity of headache, visual disturbance,​ nausea and other important symptoms (specific to the patient) as none, mild, moderate or severe. In Figure 7, Naproxen sodium produced statistically significantly superior relief of headache in comparison with placebo (p= 0.004) and the duration of headache was significantly shorter in this group than in the placebo group (p= 0.019) (Johnson et. al, 1985). Patients in the naproxen sodium group also had a significant reduction in the severity of visual disturbances when compared with those in the placebo group (= 0.049). The differences detected between the groups with respect to the severity of nausea and vomiting and the duration of the visual disturbances,​ nausea and vomiting were not significant,​ but the score for the naproxen sodium group was numerically lower for the severity of nausea and for the duration of both visual disturbances and nausea ​(Johnson et. al, 1985). Scores for the severity and duration of vomiting were the same for both groups. In summary, naproxen sodium has proved to be a drug effective in relieving symptoms associated with common migraine when taken at the onset of an attack.
-naproxen sodium group also had a significant reduction in the severity of visual disturbances when compared with those in the placebo group (= 0.049). The differences detected between the groups with respect to the severity of nausea and vomiting and the duration of the visual disturbances,​ nausea and vomiting were not significant,​ but the score for the naproxen sodium group was numerically lower for the severity of nausea and for the duration of both visual disturbances and nausea. Scores for the severity and duration of vomiting were the same for both groups. In summary, naproxen sodium has proved to be a drug effective in relieving symptoms associated with common migraine when taken at the onset of an attack.+
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 +**Calcitonin gene related peptide antagonists**
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 +Currently CGRP1 antagonists hold promise as new anti-migraine drugs. Two recently introduced are: BIBN4096BS and Compound 1 (Kalra & Elliott, 2007). BIBN4096BS was tested in the trigeminal ganglion and found to inhibit vasodilatation (Kalra & Elliott, 2007). Other experiments support its possible role as an anti-nociceptor mediator in migraine. Compound 1 has similar properties but is less potent than BIBN4096BS in human tissues (Kalra & Elliott, 2007). A third smaller CGRP antagonistic molecule is SB-273779. It has similar properties as the other two but may have greater value for the study of migraine and CGRP activity in animal models (Kalra & Elliott, 2007). The efficacy of BIBN4096BS has been tested in humans in two studies published in 2004. In the first, the safety, tolerability and pharmacokinetics of BIBN4096BS were tested in healthy volunteers. After a single IV administration of gradually increasing dose, most of the adverse events occurred at the highest administered dose (10 mg) and were relatively mild and transient (Iovino et al 2004). In another controlled study, moderate or severe headache was treated with 2.5 mg of BIBN4096BS IV vs. placebo. The end-point of pain reduction within 2 hours to mild or no pain was achieved in 66% of BIBN4096BS treated patients vs. 27% of the placebo group (Doggrell 2004). In clinical practice, its potential use will be limited to settings appropriate for IV administration.
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 **Surgery and Devices ** **Surgery and Devices **
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-Recently Plastic surgeons have advertised nerve decompression surgery as an innovative new treatment of migraine headaches. In the 1990s, the use of the muscle relaxant Botulinum toxin became popular in the treatment of chronic migraine. Its effect was thought to occur through paralysis of muscles surrounding nerves in areas of pain. This operation involves the removal of a muscle in an area of the forehead where patients experience migraine pain. The idea for surgery began with patients reporting that their headaches were disappearing after forehead rejuvenation plastic surgery.+Recently Plastic surgeons have advertised nerve decompression surgery as an innovative new treatment of migraine headaches. In the 1990s, the use of the muscle relaxant Botulinum toxin became popular in the treatment of chronic migraine. Its effect was thought to occur through paralysis of muscles surrounding nerves in areas of pain. This operation involves the removal of a muscle in an area of the forehead where patients experience migraine pain. The idea for surgery began with patients reporting that their headaches were disappearing after forehead rejuvenation plastic surgery ​(Migraine surgery Centre London, 2016).
 Combined, these observations led to a theory that migraine headache pain can be triggered by compression of superficial nerves by surrounding tissues, such as muscle, fascia, and bone. Combined, these observations led to a theory that migraine headache pain can be triggered by compression of superficial nerves by surrounding tissues, such as muscle, fascia, and bone.
-During nerve-decompression migraine surgery, nerves at one or multiple common migraine headache trigger sites are released from surrounding structures such as bone, muscle, fascia, and vessels. The Surgical Migraine Procedure is the removal of the corrugator muscles (small muscles associated with the eyebrows). However, the efficacy of this method beyond placebo has been debated in the medical community.+During nerve-decompression migraine surgery, nerves at one or multiple common migraine headache trigger sites are released from surrounding structures such as bone, muscle, fascia, and vessels ​(Migraine surgery Centre London, 2016). The Surgical Migraine Procedure is the removal of the corrugator muscles (small muscles associated with the eyebrows) (Migraine surgery Centre London, 2016). However, the efficacy of this method beyond placebo has been debated in the medical community.
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 Neurostimulation is the practice of applying gentle stimulation to nerves that have been identified as sending strong, frequent pain signals. ​ Neurostimulation is the practice of applying gentle stimulation to nerves that have been identified as sending strong, frequent pain signals. ​
    
-The Cefaly is a headband designed to deliver electrical impulses to nerves that transmit migraine pain and thereby theoretically suppress this trigger mechanism. To reduce the frequency of headaches, it is to be worn for 20 minutes every day. The device consists of a battery-operated electrical pulse generator and a self-adhesive electrode. The patient applies the electrode to the middle of the forehead and lowers a headband containing the electrical pulse generator over the forehead to engage a pin located on the electrode. Pressing a button on the band generates a pulsed electric current that stimulates the upper branches of the trigeminal nerve, producing a tingling or massaging sensation. During the treatment, which has a fixed duration of 20 minutes, the intensity of the electric current gradually increases. ​+The Cefaly is a headband designed to deliver electrical impulses to nerves that transmit migraine pain and thereby theoretically suppress this trigger mechanism. To reduce the frequency of headaches, it is to be worn for 20 minutes every day (Didier et. al, 2015). The device consists of a battery-operated electrical pulse generator and a self-adhesive electrode ​(Didier et. al, 2015). The patient applies the electrode to the middle of the forehead and lowers a headband containing the electrical pulse generator over the forehead to engage a pin located on the electrode. Pressing a button on the band generates a pulsed electric current that stimulates the upper branches of the trigeminal nerve, producing a tingling or massaging sensation ​(Didier et. al, 2015). During the treatment, which has a fixed duration of 20 minutes, the intensity of the electric current gradually increases. ​
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 +====== Conclusion ======
 +
 +Overall, migraines are a heterogenous,​ burdensome disorder that are debilitating for the individuals experiencing them. There appears to be a strong link between genetics and environment in making individuals susceptible to migraine attacks. Symptoms can vary from one individual to the next and exacerbating factors can have different effects on different individuals. Our proposed course of treatment is to use non-steroidal anti-inflammatory drugs with caffeine administration to alleviate pain in migraine sufferers. Studies have shown that NSAIDs are significantly more effective at relieving symptoms of headache compared to other proposed therapeutics. NSAIDs, like Naproxen, are much more cost-effective,​ have a longer lasting effect, have a reduced likelihood of producing rebound headaches, show low reports of adverse affects and are non-addictive. It has been shown that co-administration with caffeine promote more effective intestinal absorption and a higher likelihood of a positive treatment response. Great progress has been made in understand migraine pathophysiology as well as defining new specific therapies. In recognition of the large market of migraine sufferers, the pharmaceutical and bioengineering industries are working towards newer and better approaches for affective interventions. ​
 +
 +
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-\\====== Conclusion ====== 
  
-Overallmigraines are a heterogenousburdensome disorder that are debilitating for the individuals experiencing themThere appears to be a strong link between genetics and environment in making individuals susceptible to migraine attacksSymptoms can vary from individual to the next and exacerbating factors can have different effects on different individuals+WhalenK.Finkel, R., & Panavelil, T. A. (n.d.)Pharmacology (6th ed.).
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