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group_1_presentation_2_-_opioids [2018/03/02 23:32] mohameah |
group_1_presentation_2_-_opioids [2018/03/02 23:51] (current) alagicf |
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| ====== Adverse Effects of Opioid Use ====== | ====== Adverse Effects of Opioid Use ====== | ||
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| - | <box 25% round right | > {{ :screen_shot_2018-03-02_at_8.00.49_pm.png?200|}} </box| Figure 3: Opioid receptors in GI tract. http://slideplayer.com/slide/11681545/ > | ||
| There are various adverse effects associated with long term use of opioids (Voon, Karamouzian & Kerr, 2017). These effects have been shown to target the gastrointestinal, cardiovascular, respiratory and central nervous systems (Voon, Karamouzian & Kerr, 2017). With regards to the gastrointestinal system, constipation is a prevalent effect of chronic opiate therapy (Khansari, Sohrabi & Zamani, 2013). This process depends on the stimulation of μ and κ opioid receptors in the gastrointestinal tract. Studies show that 40-45% of patients on opiate therapy experience constipation. Treatment involves the use of stool softeners and laxatives, which is not always effective. In some cases, constipation can be so severe that patients reduce their medication dosage or discontinue opiate use altogether (Khansari, Sohrabi & Zamani, 2013). | There are various adverse effects associated with long term use of opioids (Voon, Karamouzian & Kerr, 2017). These effects have been shown to target the gastrointestinal, cardiovascular, respiratory and central nervous systems (Voon, Karamouzian & Kerr, 2017). With regards to the gastrointestinal system, constipation is a prevalent effect of chronic opiate therapy (Khansari, Sohrabi & Zamani, 2013). This process depends on the stimulation of μ and κ opioid receptors in the gastrointestinal tract. Studies show that 40-45% of patients on opiate therapy experience constipation. Treatment involves the use of stool softeners and laxatives, which is not always effective. In some cases, constipation can be so severe that patients reduce their medication dosage or discontinue opiate use altogether (Khansari, Sohrabi & Zamani, 2013). | ||
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| + | <box 35% round right | > {{ :screen_shot_2018-03-02_at_8.00.49_pm.png?350|}} </box| Figure 3: Opioid receptors in GI tract. http://slideplayer.com/slide/11681545/ > | ||
| Long term use of opioid therapy has been shown to have deleterious effects on the cardiovascular system (Chen & Ashburn, 2015). When the use of opioid therapy was compared to Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors, opioid therapy was associated with a 77% increased risk of cardiovascular effects such as heart failure and myocardial infarction (MI) (Voon, Karamouzian & Kerr, 2017). After 30 days, the risk of cardiovascular events was similar across different opioid medications. However, after 180 days of therapy, codeine was associated with a 62% increase in adverse events when compared to hydrocodone (Voon, Karamouzian & Kerr, 2017). Furthermore, studies have shown an increased risk of MI among patients on chronic opioid therapy relative to the general population (Chen & Ashburn, 2015). | Long term use of opioid therapy has been shown to have deleterious effects on the cardiovascular system (Chen & Ashburn, 2015). When the use of opioid therapy was compared to Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors, opioid therapy was associated with a 77% increased risk of cardiovascular effects such as heart failure and myocardial infarction (MI) (Voon, Karamouzian & Kerr, 2017). After 30 days, the risk of cardiovascular events was similar across different opioid medications. However, after 180 days of therapy, codeine was associated with a 62% increase in adverse events when compared to hydrocodone (Voon, Karamouzian & Kerr, 2017). Furthermore, studies have shown an increased risk of MI among patients on chronic opioid therapy relative to the general population (Chen & Ashburn, 2015). | ||
