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public:research 2021/07/02 18:06 public:research 2022/04/21 02:32 current
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**Publications:** **Publications:**
-  * Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, "Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications," IEEE Selected Topics in Quantum Electronics, 27(5):1-9, doi.org/10.1109/JSTQE.2020.2997834  ({{:public:publications:mcfocal_flim_2020_jstqe_pre.pdf|Preprint PDF}})+  * Elizabeth J. Osterlund, Nehad Hirmiz, James M. Pemberton, Adrien Nougarede, Qian Liu, Brian Leber, Qiyin Fang, and David W. Andrews, "Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells," Science Advances, 8(16): 2022, doi: 10.1126/sciadv.abm7375 ([[https://doi.org/10.1126/sciadv.abm7375|Open Access]]) 
 +  * Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, "Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications," IEEE Selected Topics in Quantum Electronics, 27(5):1-9, 2020, doi.org/10.1109/JSTQE.2020.2997834  ({{:public:publications:mcfocal_flim_2020_jstqe_pre.pdf|Preprint PDF}})
  * Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, "Multiplexed confocal microscope with a refraction window scanner and a single-photon avalanche photodiode array detector," Opt. Lett. 45(1), 69-72 (2020), https://doi.org/10.1364/OL.45.000069 ([[https://doi.org/10.1364/OL.45.000069|online]])   * Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, "Multiplexed confocal microscope with a refraction window scanner and a single-photon avalanche photodiode array detector," Opt. Lett. 45(1), 69-72 (2020), https://doi.org/10.1364/OL.45.000069 ([[https://doi.org/10.1364/OL.45.000069|online]])
  * Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, "Cross-talk reduction in a multiplexed synchroscan streak camera with simultaneous calibration," Opt. Express 27, 22602-22614 (2019), doi.org/10.1364/OE.27.022602 ([[https://doi.org/10.1364/OE.27.022602|online]])   * Nehad Hirmiz, Anthony Tsikouras, Elizabeth J. Osterlund, Morgan Richards, David W. Andrews, and Qiyin Fang, "Cross-talk reduction in a multiplexed synchroscan streak camera with simultaneous calibration," Opt. Express 27, 22602-22614 (2019), doi.org/10.1364/OE.27.022602 ([[https://doi.org/10.1364/OE.27.022602|online]])
  * Anthony Tsikouras, Pietro Peronio, Ivan Rech, Nehad Hirmiz, M. Jamal Deen, and Qiyin Fang, "Characterization of SPAD Array for Multifocal High-Content Screening Applications," Photonics 3(4):56, 2016; doi: 10.3390/photonics3040056, ([[http://www.mdpi.com/2304-6732/3/4/56/html|Open Access]])   * Anthony Tsikouras, Pietro Peronio, Ivan Rech, Nehad Hirmiz, M. Jamal Deen, and Qiyin Fang, "Characterization of SPAD Array for Multifocal High-Content Screening Applications," Photonics 3(4):56, 2016; doi: 10.3390/photonics3040056, ([[http://www.mdpi.com/2304-6732/3/4/56/html|Open Access]])
  *  Anthony Tsikouras, Richard Berman, David W. Andrews and Qiyin Fang, "High-speed multifocal array scanning using refractive window tilting," Biomedical Optics Express 6, 3737-3757, 2015. ([[https://www.osapublishing.org/boe/abstract.cfm?uri=boe-6-10-3737|Open Access]])   *  Anthony Tsikouras, Richard Berman, David W. Andrews and Qiyin Fang, "High-speed multifocal array scanning using refractive window tilting," Biomedical Optics Express 6, 3737-3757, 2015. ([[https://www.osapublishing.org/boe/abstract.cfm?uri=boe-6-10-3737|Open Access]])
-  * Anthony Tsikouras, Jin Ning, Sandy Ng, Rirchard Berman, David W. Andrews, and Qiyin Fang, “Streak camera crosstalk reduction using  a multiple decay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012. ({{:public:publications:fangq_tsikourasa_streak-flim_ol_2012.pdf|PDF}})\\+  * Anthony Tsikouras, Jin Ning, Sandy Ng, Richard Berman, David W. Andrews, and Qiyin Fang, “Streak camera crosstalk reduction using  a multiple decay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012. ({{:public:publications:fangq_tsikourasa_streak-flim_ol_2012.pdf|PDF}})\\
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==== Imaging in the Gastrointestinal Tract ("Google Streetview" of the Colon) ==== ==== Imaging in the Gastrointestinal Tract ("Google Streetview" of the Colon) ====
-We are developing a novel 360 degree panoramic imaging method to build a map of colon lining, during colonoscopy, and use it to locate and track cancerous and pre-cancerous lesions. In colonoscopy, it is important to monitor the progression or recurrence of suspected cancerous lesions (e.g. polyps). Because the colon is contractile and mobile, however, it is very difficult to relocate a lesion (e.g. a polyp) even during the same procedure. A near-infrared imager will be built to image the blood vessels under the surface of the colon lining. The infrared images will be merged with regular surface images to build a colon map that shows blood vessel features as landmarks. This research will make colon cancer screening and treatments more effective.  +In colonoscopy, it is important to monitor the progression or recurrence of suspected cancerous lesions (e.g., polyps). Because the colon is contractile and mobile, however, it is very difficult to relocate a lesion (e.g., a polyp) even during the same procedure. We are developing a novel 360 degree panoramic imaging method to build a map of colon lining, during colonoscopy, and use it to locate and track cancerous and pre-cancerous lesions. This research will make colon cancer screening and treatments more effective. 
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**Publications:** **Publications:**
-  *  Samir Sahli, Roy, C. C. Wang, Aparna Murthy, David Armstrong, M. Jamal Deen, and Qiyin Fang, "a 360 degree side view endoscope for lower GI tract mapping," Physics in Canada, 71(1): 18-20, 2015+  *  Samir Sahli, Roy, C. C. Wang, Aparna Murthy, David Armstrong, M. Jamal Deen, and Qiyin Fang, "a 360 degree side view endoscope for lower GI tract mapping," Physics in Canada, 71(1): 18-20, 2015 ([[https://pic-pac.cap.ca/index.php/Issues/showpdf/article/v71n1.0-a2394.pdf|online]])
  * Roy Chih Chung Wang, M. Jamal Deen, David Armstrong, and Qiyin Fang, "development of a catadioptric endoscope objective with forward and side views," Journal of Biomedical Optics, 16(6):066015, 2011. ({{:public:publications:fangq_wangrcc_dual-view_jbo_2011.pdf|PDF}})   * Roy Chih Chung Wang, M. Jamal Deen, David Armstrong, and Qiyin Fang, "development of a catadioptric endoscope objective with forward and side views," Journal of Biomedical Optics, 16(6):066015, 2011. ({{:public:publications:fangq_wangrcc_dual-view_jbo_2011.pdf|PDF}})
-  * M. Kfouri, O. Marinov, P. Quevedo, N. Faramarzpour, S. Shirani, L. W-C. Liu, Q. Fang, M. J. Deen, “Towards a Miniaturized Wireless Fluorescence-Based Diagnostic Imaging System,” IEEE Journal of Se-lected Topics in Quantum Electronics, 14(1): 226-234, 2008. ({{:public:publications:kfourim_ieee_2008.pdf|PDF}})  +  * M. Kfouri, O. Marinov, P. Quevedo, N. Faramarzpour, S. Shirani, L. W-C. Liu, Q. Fang, M. J. Deen, “Towards a Miniaturized Wireless Fluorescence-Based Diagnostic Imaging System,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 226-234, 2008. ({{:public:publications:kfourim_ieee_2008.pdf|PDF}}) 
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==== Micro and Nano-Biosensing/Imaging Devices ==== ==== Micro and Nano-Biosensing/Imaging Devices ====
Conventional optical spectroscopy and imaging systems are large, complex and costly optoelectronic instruments comprised of lasers, spectrophotometers, and detectors. Often, their size is the limiting factor for their use in certain applications such as in-situ monitoring of physiological processes and distributed environmental sensing. In practice, there are strong demands for miniaturized, integrated devices for biomedical applications. Conventional optical spectroscopy and imaging systems are large, complex and costly optoelectronic instruments comprised of lasers, spectrophotometers, and detectors. Often, their size is the limiting factor for their use in certain applications such as in-situ monitoring of physiological processes and distributed environmental sensing. In practice, there are strong demands for miniaturized, integrated devices for biomedical applications.
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  * Eric Mahoney, Huan-Huan Hsu, Fei Du, Bo Xiong, P. Ravi Selvaganapathy, and Qiyin Fang, "Optofluidic Dissolved Oxygen Sensing With Sensitivity Enhancement Through Multiple Reflections," IEEE Sensors 19(22): 10452-10460, 2019, doi.org/10.1109/JSEN.2019.2932414 ([[https://doi.org/10.1109/JSEN.2019.2932414|online]])   * Eric Mahoney, Huan-Huan Hsu, Fei Du, Bo Xiong, P. Ravi Selvaganapathy, and Qiyin Fang, "Optofluidic Dissolved Oxygen Sensing With Sensitivity Enhancement Through Multiple Reflections," IEEE Sensors 19(22): 10452-10460, 2019, doi.org/10.1109/JSEN.2019.2932414 ([[https://doi.org/10.1109/JSEN.2019.2932414|online]])
  *  Christina M. Gabardo, Robert C. Adams-McGavin, Barnabas C. Fung, Eric J. Mahoney, Qiyin Fang, Leyla Soleymani, “Rapid prototyping of all-solution-processed multi-lengthscale electrodes using polymer-induced thin film wrinkling,” Scientific Reports 7, 42543, 2017. ([[http://www.nature.com/articles/srep42543|Open Access]])   *  Christina M. Gabardo, Robert C. Adams-McGavin, Barnabas C. Fung, Eric J. Mahoney, Qiyin Fang, Leyla Soleymani, “Rapid prototyping of all-solution-processed multi-lengthscale electrodes using polymer-induced thin film wrinkling,” Scientific Reports 7, 42543, 2017. ([[http://www.nature.com/articles/srep42543|Open Access]])
-  *  S. C. Goh, Y. Luan, X.g Wang, H. Du, C. Chau, H. E. Schellhorn, J. L. Brash, H. Chen, and Q. Fang, “Polydopamine-polyethylene glycol-albumin antifouling coatings on multiple substrates,” Journal of Materials Chemistry B, 6: 940-949, 2018 ([[http://pubs.rsc.org/en/Content/ArticleLanding/2018/TB/C7TB02636F#!divAbstract|Online]])+  *  S. C. Goh, Y. Luan, XG Wang, H. Du, C. Chau, H. E. Schellhorn, J. L. Brash, H. Chen, and Q. Fang, “Polydopamine-polyethylene glycol-albumin antifouling coatings on multiple substrates,” Journal of Materials Chemistry B, 6: 940-949, 2018 ([[http://pubs.rsc.org/en/Content/ArticleLanding/2018/TB/C7TB02636F#!divAbstract|Online]])
  *  Yushan Zhang, Benjamin R. Watts, Tianyi Guo, Zhiyi Zhang, Changqing Xu, and Qiyin Fang, "Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review," Micromachines 7(4): 70, 2016; doi: 10.3390/mi7040070.  ([[http://www.mdpi.com/2072-666X/7/4/70/html|Open Access]])   *  Yushan Zhang, Benjamin R. Watts, Tianyi Guo, Zhiyi Zhang, Changqing Xu, and Qiyin Fang, "Optofluidic Device Based Microflow Cytometers for Particle/Cell Detection: A Review," Micromachines 7(4): 70, 2016; doi: 10.3390/mi7040070.  ([[http://www.mdpi.com/2072-666X/7/4/70/html|Open Access]])
  *  Tianyi Guo, M. Jamal Deen, C-Q, Xu, Qiyin Fang, P. Ravi Selvaganapathy, Haiying Zhang, “Observation of ultraslow stress release in silicon nitride film on CaF2,” J. of Vacuum Science & Technology A, 33, 041515, 2015 ({{:public:publications:deenmj_guot_fangq_sin_2015.pdf|PDF}})   *  Tianyi Guo, M. Jamal Deen, C-Q, Xu, Qiyin Fang, P. Ravi Selvaganapathy, Haiying Zhang, “Observation of ultraslow stress release in silicon nitride film on CaF2,” J. of Vacuum Science & Technology A, 33, 041515, 2015 ({{:public:publications:deenmj_guot_fangq_sin_2015.pdf|PDF}})
  *  R. Liu, Z. Zhao, L. Zou, Q. Fang, L. Chen, A. Argento, J. F. Lo, "Compact, non-invasive frequency domain lifetime differentiation of collagens and elastin," Sensors and Actuators, B: Chemical, 219(8): 289-293, 2015 ({{:public:publications:lojf_liur_fangq_fd_lifetime_collagen_elastin_2015.pdf|PDF}})   *  R. Liu, Z. Zhao, L. Zou, Q. Fang, L. Chen, A. Argento, J. F. Lo, "Compact, non-invasive frequency domain lifetime differentiation of collagens and elastin," Sensors and Actuators, B: Chemical, 219(8): 289-293, 2015 ({{:public:publications:lojf_liur_fangq_fd_lifetime_collagen_elastin_2015.pdf|PDF}})
-  *  Tianyi Guo, Yin Wei, Changqing Xu, Benjamin R. Watts, Zhiyi Zhang, Qiyin Fang, Haiying Zhang, P. Ravi Selvaganapathy, and M. Jamal Deen,"Counting of E. Coli by a Micro-flow Cytometer Based on a Photonic-Microfluidic Integrated Device," Electrophoresis, 36(2): 298-304, 2015 ({{:public:publications:xucq_guoty_optofluidics_bact_2014.pdf|PDF}}). +  *  Tianyi Guo, Yin Wei, Changqing Xu, Benjamin R. Watts, Zhiyi Zhang, Qiyin Fang, Haiying Zhang, P. Ravi Selvaganapathy, and M. Jamal Deen, "Counting of E. Coli by a Micro-flow Cytometer Based on a Photonic-Microfluidic Integrated Device," Electrophoresis, 36(2): 298-304, 2015 ({{:public:publications:xucq_guoty_optofluidics_bact_2014.pdf|PDF}}).
  *  Leo Hsu, P. Ravi Selvaganapathy, J. Brash, Q. Fang, C-Q. Xu, M. Jamal Deen, and Hong Chen, "Development of a low-cost Hemin-based dissolved oxygen sensor with anti-biofouling coating for water monitoring,” IEEE Sensors, 14(10):3400-3407, 2014 ({{:public:publications:hsuhh_do_ieee-sensor_2014.pdf|PDF}})   *  Leo Hsu, P. Ravi Selvaganapathy, J. Brash, Q. Fang, C-Q. Xu, M. Jamal Deen, and Hong Chen, "Development of a low-cost Hemin-based dissolved oxygen sensor with anti-biofouling coating for water monitoring,” IEEE Sensors, 14(10):3400-3407, 2014 ({{:public:publications:hsuhh_do_ieee-sensor_2014.pdf|PDF}})
  * Zhiyun Li, M. Jamal Deen, Qiyin Fang, and P. R. Selvaganapathy, "Design of a flat field concave-grating-based micro-Raman spectrometer for environmental applications," Applied Optics, 51(28):6855-6863, 2012 ({{:public:publications:liz_concave-grating_ao_2012.pdf|PDF}}).   * Zhiyun Li, M. Jamal Deen, Qiyin Fang, and P. R. Selvaganapathy, "Design of a flat field concave-grating-based micro-Raman spectrometer for environmental applications," Applied Optics, 51(28):6855-6863, 2012 ({{:public:publications:liz_concave-grating_ao_2012.pdf|PDF}}).
  * Munir El-Desouki, Ognian Marinov, M. Jamal Deen, Qiyin Fang, "CMOS Active-Pixel Sensor With In-Situ Memory for Ultrahigh-Speed Imaging," IEEE Sensors Journal, 11(6): 1375-1379, 2011. ({{:public:publications:deenmj_el-desoukimm_marinovo_fangq_ieee_sensors_2011.pdf|PDF}})   * Munir El-Desouki, Ognian Marinov, M. Jamal Deen, Qiyin Fang, "CMOS Active-Pixel Sensor With In-Situ Memory for Ultrahigh-Speed Imaging," IEEE Sensors Journal, 11(6): 1375-1379, 2011. ({{:public:publications:deenmj_el-desoukimm_marinovo_fangq_ieee_sensors_2011.pdf|PDF}})
-  * Munir El-Desouki, Darek Palubiak, M. Jamal Deen, Qiyin Fang, Ognian Marinov, "A novel, high-dynamic range, high-speed, and high sensitibility CMOS imager using time-domain single-photon counting and avalanche photodiodes," IEEE Sensors Journal, 11(4): 1078-1083, 2011. ({{:public:publications:deenmj_el-desoukimm_marinovo_fangq_ieee_sensors_2011a.pdf|PDF}}) +  * Munir El-Desouki, Darek Palubiak, M. Jamal Deen, Qiyin Fang, Ognian Marinov, "A novel, high-dynamic range, high-speed, and high sensitivity CMOS imager using time-domain single-photon counting and avalanche photodiodes," IEEE Sensors Journal, 11(4): 1078-1083, 2011. ({{:public:publications:deenmj_el-desoukimm_marinovo_fangq_ieee_sensors_2011a.pdf|PDF}})
  * J. F. Lo, P. Butte, Q. Fang, S. J. Chen, T. Papaioannou, E. S. Kim, M. Gundersen, L. Marcu, "Multilayered MOEMS tunable spectrometer for fluorescence lifetime detection," IEEE Photonics Technology Letters, 20(7):486-488, 2010.  ({{:public:publications:loj_ieee_photonics_2010.pdf|PDF}})   * J. F. Lo, P. Butte, Q. Fang, S. J. Chen, T. Papaioannou, E. S. Kim, M. Gundersen, L. Marcu, "Multilayered MOEMS tunable spectrometer for fluorescence lifetime detection," IEEE Photonics Technology Letters, 20(7):486-488, 2010.  ({{:public:publications:loj_ieee_photonics_2010.pdf|PDF}})
  * Joe Lo, Shi-Jui Chen, Qiyin Fang, Thanassis Papaioannou, Eun-Sok Kim, Martin Gundersen and Laura Marcu, “Performance of Diaphragmed Microlens for a Packaged Microspectrometer,” Sensors, 9: 859-868, 2009 ({{:public:publications:loj_sensors_2009.pdf|PDF}})   * Joe Lo, Shi-Jui Chen, Qiyin Fang, Thanassis Papaioannou, Eun-Sok Kim, Martin Gundersen and Laura Marcu, “Performance of Diaphragmed Microlens for a Packaged Microspectrometer,” Sensors, 9: 859-868, 2009 ({{:public:publications:loj_sensors_2009.pdf|PDF}})

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