Differences

This shows you the differences between the selected revision and the current version of the page.

public:research:flim 2025/05/03 18:04 public:research:flim 2026/03/02 19:03 current
Line 4: Line 4:
We have developed a suite of technologies to generate, scan, and measure 1000+ confocal foci simultaneously, while is compatible with stationary discrete detectors. Another key feature of the technique is that it can be retrofitted to a conventional wide-field fluorescence microscope. We are also developing various related technologies for its applications in drug discovery and in vivo imaging.  We have developed a suite of technologies to generate, scan, and measure 1000+ confocal foci simultaneously, while is compatible with stationary discrete detectors. Another key feature of the technique is that it can be retrofitted to a conventional wide-field fluorescence microscope. We are also developing various related technologies for its applications in drug discovery and in vivo imaging. 
 +
 +\\
 +
 +**Biological Applications**
 +
 +On the biomedical side, we are working on the development of imaging assay workflows and protocols involving standard live cell models. We are currently optimizing fluorescent protein expression and running system validations using various standard colocalization and FRET experiments. We plan to apply this workflow to examine various dynamic processes including calcium signalling, metabolic activity, and oxidative stress. The spatial, temporal, and time-lapse imaging data can be used to understand pathophysiological states and their dose-dependent and time-dependent responses to various drugs and environmental stimuli.     
\\ \\
Line 20: Line 26:
  *  Zhaojun Nie, Ran An, Joseph E. Hayward, Thomas J. Farrell, Qiyin Fang, "Hyperspectral fluorescence lifetime imaging for optical biopsy," Journal of Biomedical Optics 18 (9):096001,  2013, doi: 10.1117/1.JBO.18.9.096001, ({{:public:publications:fangq_niez_jbo_2013.pdf|PDF}})   *  Zhaojun Nie, Ran An, Joseph E. Hayward, Thomas J. Farrell, Qiyin Fang, "Hyperspectral fluorescence lifetime imaging for optical biopsy," Journal of Biomedical Optics 18 (9):096001,  2013, doi: 10.1117/1.JBO.18.9.096001, ({{:public:publications:fangq_niez_jbo_2013.pdf|PDF}})
  * Anthony Tsikouras, Jin Ning, Sandy Ng, Richard Berman, David W. Andrews, and Qiyin Fang, “Streak camera crosstalk reduction using  a multiple decay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012. ({{:public:publications:fangq_tsikourasa_streak-flim_ol_2012.pdf|PDF}})\\   * Anthony Tsikouras, Jin Ning, Sandy Ng, Richard Berman, David W. Andrews, and Qiyin Fang, “Streak camera crosstalk reduction using  a multiple decay optical fiber bundle,” Optics Letters 37(2): 250-252, 2012. ({{:public:publications:fangq_tsikourasa_streak-flim_ol_2012.pdf|PDF}})\\
 +
 +** Related work on single photon detectors **
 +  * Munir El-Desouki, Ognian Marinov, M. Jamal Deen, Qiyin Fang, "CMOS Active-Pixel Sensor With In-Situ Memory for Ultrahigh-Speed Imaging," IEEE Sensors Journal, 11(6): 1375-1379, 2011. ({{:public:publications:deenmj_el-desoukimm_marinovo_fangq_ieee_sensors_2011.pdf|PDF}})
 +  * Munir El-Desouki, Darek Palubiak, M. Jamal Deen, Qiyin Fang, Ognian Marinov, "A novel, high-dynamic range, high-speed, and high sensitivity CMOS imager using time-domain single-photon counting and avalanche photodiodes," IEEE Sensors Journal, 11(4): 1078-1083, 2011. ({{:public:publications:deenmj_el-desoukimm_marinovo_fangq_ieee_sensors_2011a.pdf|PDF}})
 +  * N. Faramarzpour, M. M. El-Desouki, M. J. Deen, S. Shirani, Q. Fang, “CMOS photodetector systems for low-level light applications,” Journal of Material Sciences: Materials in Electronics, invited, 20(S1): 87-93, 2009. ({{:public:publications:faramarzpourn_mater_2009.pdf|PDF}})
 +  * N. Faramarzpour, M. J. Deen, S. Shirani and Q. Fang, “Fully Integrated Single Photon Avalanche Diode Detector in Standard CMOS 0.18μm Technology,” IEEE Transactions on Electron Devices, Vol. 55(3): 760-767, 2008. ({{:public:publications:faramarzpourn_ieee_2008.pdf|PDF}})
 +  * N. Faramarzpour, M. M. El-Desouki, M. J. Deen, Q. Fang, S. Shrani and L. W-C. Liu, “CMOS Imaging for Biomedical Applications,” IEEE Potentials, May/June: 31-36, 2008. ({{:public:publications:faramarzpourn_ieee_potentials_2007.pdf|PDF}})
 +  * N. Faramarzpour, M. J. Deen, S. Shirani, Q. Fang, L. W. C. Liu, F. Campos, and J. W. Swart, “CMOS based active pixel for low-light-level detection: analysis and measurements,” IEEE Transactions on Elec-tron Devices, 54(12): 3229-3237, 2007. ({{:public:publications:faramarzpourn_ieee_2007.pdf|PDF}})
\\ \\

Navigation
Personal Tools