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| We have developed a suite of technologies to generate, scan, and measure 1000+ confocal foci simultaneously, while is compatible with stationary discrete detectors. Another key feature of the technique is that it can be retrofitted to a conventional wide-field fluorescence microscope. We are also developing various related technologies for its applications in drug discovery and in vivo imaging. | We have developed a suite of technologies to generate, scan, and measure 1000+ confocal foci simultaneously, while is compatible with stationary discrete detectors. Another key feature of the technique is that it can be retrofitted to a conventional wide-field fluorescence microscope. We are also developing various related technologies for its applications in drug discovery and in vivo imaging. | ||
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| + | **Biological Applications** | ||
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| + | On the biomedical side, we are working on the development of imaging assay workflows and protocols involving standard live cell models. We are currently optimizing fluorescent protein expression and running system validations using various standard colocalization and FRET experiments. We plan to apply this workflow to examine various dynamic processes including calcium signalling, metabolic activity, and oxidative stress. The spatial, temporal, and time-lapse imaging data can be used to understand pathophysiological states and their dose-dependent and time-dependent responses to various drugs and environmental stimuli. | ||
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