Optical Biopsy Theme

Optical Biopsy: to provide clinical information equivalent to that available from a physical biopsy. Usually assumed to mean equivalent to information available from stained sections of formalin fixed paraffin embedded biopsy tissue, specifically pathological assessment of same.

Point Spectroscopy

Reflectance & Fluorescence
	Spatially Resolved
	Polarized
	Time Domain		
Raman
IR

In Vivo Microscopic Imaging

       Confocal Reflectance & Fluorescence Microscopy
       Multi Photon Microscopy
       Optical Coherence Tomography

Haisha Zheng: Raman, Reflectance and Fluorescence Spectroscopy, multi-photon (Skin, Lung, GI)

Calum MacAulay: OCT, reflectance and fluorescence spectroscopy, In vivo confocal microendscopy (Lung, Oral, Cervix, GI)

Pierre Lane: OCT, reflectance and fluorescence spectroscopy, In vivo confocal microendscopy, multi-photon (Lung, Cervix, Ovarian)

Sensitivity and Specificity

Identifying opportunities/indications needing/requiring immediate clinical action (see and treat methodology) since in the genomic age if a biopsy can be taken it will be for conventional pathology (current practice) and genetic/genomic analysis (future studies)

Brain, Heart, etc (tissues for which biopsy entails significant clinical risk)

Screening settings in which low specificity of primary test could result in too frequent biopsy which induces costs or morbidity (Oral, Skin, etc)