Optical Biopsy Theme

Optical Biopsy: to provide clinical information equivalent to that available from a physical biopsy. Usually assumed to mean equivalent to information available from stained sections of formalin fixed paraffin embedded biopsy tissue, specifically pathological assessment of same.

Point Spectroscopy

Reflectance & Fluorescence
	Spatially Resolved
	Polarized
	Time Domain		
Raman
IR

In Vivo Microscopic Imaging

       Confocal Reflectance & Fluorescence Microscopy
       Multi Photon Microscopy
       Optical Coherence Tomography

Haisha Zheng: Raman, Reflectance and Fluorescence Spectroscopy (Skin, Lung, GI)

Calum MacAulay: OCT, reflectance and fluorescence spectroscopy, In vivo confocal microendscopy (Lung, Oral, Cervix, GI)

Pierre Lane: OCT, reflectance and fluorescence spectroscopy, In vivo confocal microendscopy (Lung, Cervix, Ovarian)

Sensitivity and Specificity

Identifying opportunities/indications needing/requiring immediate clinical action (see and treat methodology) since in the genomic age if a biopsy can be taken it will be for conventional pathology (current practice) and genetic/genomic analysis (future studies)