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public:ccsip:optical_biopsy 2010/11/23 23:01 public:ccsip:optical_biopsy 2010/11/24 11:10 current
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-====== Optical Biopsy Theme ======+====== Optical Biopsy (Tissue level) Theme ======
===== Description of the Technology ===== ===== Description of the Technology =====
-  +Optical Biopsy: to provide clinical information equivalent to that available from a physical biopsy. Usually assumed to mean equivalent to information available from stained sections of formalin fixed paraffin embedded biopsy tissue, specifically pathological assessment of same.   
==== Basic modalities ==== ==== Basic modalities ====
 +  * Point Spectroscopy
 +      * Reflectance & Fluorescence
 +      * Raman
 +      * IR
 +      * Spatially resolved, Time Domain, Polarized
==== Current research in the group ==== ==== Current research in the group ====
 +**UBC: Calum MacAulay, Haisha Zheng, Pierre Lane**: \\
 +Raman, Reflectance and Fluorescence Spectroscopy, In vivo confocal microendscopy, multi-photon\\
 +Anatomical Location: Skin, Lung, GI, Cervix\\
 +
 +**McMaster: Qiyin Fang, Joe Hayward, Tom Farrell, Mike Patterson**: \\
 +Time-resolved fluorescence spectroscopy & imaging, Diffused Reflectance + TRF; \\
 +Anatomical Location: Brain, GI, Lung\\
 +
 +**UCLA: Warren Grundfest, William H. Yong** \\
 +
 +**UC Irvine: **
 +
===== Challenges ===== ===== Challenges =====
 +Sensitivity and Specificity
-==== Significant clinical prblems ====+Identifying opportunities/indications needing/requiring immediate clinical action (see and treat methodology) since in the genomic age if a biopsy can be taken it will be for conventional pathology (current practice) and genetic/genomic analysis (future studies) 
 + 
 +==== Significant clinical problems ==== 
 +Brain, Heart, etc (tissues for which biopsy entails significant clinical risk) 
 + 
 +Screening settings in which low specificity of primary test could result in too frequent biopsy which induces costs or morbidity (Oral, Skin, etc)
==== Key technology barriers ==== ==== Key technology barriers ====
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==== potential industrial partners ==== ==== potential industrial partners ====
 +
 +===== References =====

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