Zhaojun Nie 聂肇君

Graduate student, PhD Candidate. Biomedical Engineering, McMaster University
M.Sc Optoelectronic Engineering, Beijing Institute of Technology
B.S Optical Information Science & Technology, Xi'an Institute of Post and Telecomunication.

Office: ITB 112
Email: niez2@mcmaster.ca

Mailing Address
ETB 405 School of Biomedical Engineering
McMaster University
1280 Main Street West
Hamilton, ON L8S 4L7, Canada

my research focus on：
Integrated system of time-resolved fluoresecence spectroscopy and diffuse reflectance spectroscopy for optical biopsy
Abstract:
Time resolved fluorescence (TRF) spectroscopy and diffuse reflectance (DR) spectroscopy have been used as minimally-invasive optical biopsy modalities. They offer real-time alternatives to invasive tissue biopsies. Fluorescence lifetime is independent of intensity variations and adds an additional source of contrast compared to steady state fluorescence. Diffuse reflectance allows for quantitative measurement of optical properties of tissue. Combining both DR and TRF modalities in one optical biopsy instrument allows for the integration of diffuse reflectance, time-resolved, and steady-state spectra for tissue diagnosis as well as real-time correction of the fluorescence lifetime and spectrum based on optical property measurements in-situ. We have designed and developed an integrated clinically compatible apparatus which acquires time-resolved fluorescence and diffuse reflectance simultaneously. We have also designed and fabricated a dual modality, compact fiber-optic probe for fluorescence and diffuse reflectance signal collection. The performance of the system was evaluated and calibrated using a fluorescence tissue phantom model.

Conference :Thanking Ahead For a Strong Future Canada Research Chairs
Location: Metro Toronto Convention Centre, Toronto, Canada
Date: November 24th –25th ,2010
Poster name: Time-Resolved Fluorescence based optical biopsy technology development
Authors: Zhaojun Nie, Derek Capon, Joseph E. Hayward, Thomas Farrell, and Qiyin Fang

Conference :2011 SPIE photonics west
Location: The Moscone Center, San Francisco , US
Date: January 21st -27th ,2011
Presentation : Integrated Time-resolved Fluorescence and Diffuse Reflectance Spectroscopy Optical Biopsy Instrument
Authors: Zhaojun Nie, Derek Cappon, Joseph E. Hayward, Thomas J. Farrell, Michael S. Patterson, John Provias, Naresh Murty, William McMillan, and Qiyin Fang

Conference :9th Annual World Congress of SBMT on Brain, Spinal Cord Mapping and Image Guided Therapy
Location: Metro Toronto Convention Centre, Toronto, Canada
Date: June 2-4,2012
Presentation : Integrated Time-resolved Fluorescence and Diffuse Reflectance Spectroscopy Optical Biopsy Instrument
Authors: Zhaojun Nie, Derek Cappon, Joseph E. Hayward, Thomas J. Farrell, Michael S. Patterson, John Provias, Naresh Murty, William McMillan, Brian Pikul, William H. Yong ,and Qiyin Fang

Derek J. Cappon, Zhaojun Nie, Thomas J. Farrell, Qiyin Fang, and Joseph E. Hayward,”A Novel Optical Property Recovery Algorithm for Use in the Optical Biopsy of Brain Tissue”Digital Holography and Three-Dimensional Imaging, OSA Technical Digest (Optical Society of America, 2012)