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group_5_presentation_2_-_hyperbilirubinemia_jaundice [2017/10/31 15:23] mohamesb [Exchange Transfusions] |
group_5_presentation_2_-_hyperbilirubinemia_jaundice [2018/01/25 15:18] (current) |
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| + | **LS4M03 ppt link:** [[https://docs.google.com/presentation/d/17I4UVA_GAagsoywBAQvyIQ6UZCuQBjTS8bzAhAupoAA/edit?usp=sharing]] | ||
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| ====== Introduction ====== | ====== Introduction ====== | ||
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| ==== Exchange Transfusions ==== | ==== Exchange Transfusions ==== | ||
| - | Blood exchange transfusion consists of slowly replacing the recipient’s blood with donor blood, which helps to lower the bilirubin levels. This once was the main treatment for neonatal jaundice until phototherapy was discovered. Exchange transfusion is rare in developed countries, and it is only used in emergencies of severe hyperbilirubinemia when phototherapy is not proving to be adequately fast (Murki & Kumar, 2011). Prenatal and postnatal care has also significantly improved over time, which has been shown to be a factor in the decline of the frequency of exchange transfusions (Steiner, Bizzarro, Ehrenkranz, et. al, 2007). On the other hand, exchange transfusions are quite common in developing countries (Murki & Kumar, 2011). | + | Blood exchange transfusion consists of slowly replacing the recipient’s blood with donor blood, which helps to lower the bilirubin levels. This once was the main treatment for neonatal jaundice until phototherapy was discovered. Exchange transfusion is rare in more developed countries, and it is only used in emergencies of severe hyperbilirubinemia when phototherapy is not proving to be adequately fast (Murki & Kumar, 2011). Prenatal and postnatal care has also significantly improved over time, which has been shown to be a factor in the decline of the frequency of exchange transfusions (Steiner, Bizzarro, Ehrenkranz, et. al, 2007). On the other hand, exchange transfusions are still quite common in developing countries that lack sufficient resources for phototherapy (Murki & Kumar, 2011). |
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| ====== Implications & Future Research ====== | ====== Implications & Future Research ====== | ||
| - | ====Protective effects of Mild Hyperbilirubinemia==== | + | ====Protective Effects of Mild Hyperbilirubinemia==== |
| Interestingly, bilirubin is a strong antioxidant and mild hyperbilirubinemia may have a protective effect against ischemic cardiovascular disease and cancer (Wang, Chowdhury J & Chowdhury N, 2006). In fact, a recent study looking at the history of colorectal cancer done on a large population reported the odds ratios to be reduced to 0.295 in men and 0.186 in women per 1 mg/dl increment in serum bilirubin levels (Wang, Chowdhury J & Chowdhury N, 2006). Furthermore, an inverse relationship between serum bilirubin levels and cancer mortality has also been reported (Wang, Chowdhury J & Chowdhury N, 2006). However, these findings do not suggest a direct cause-and-effect relationship and more research needs to be done in this area. | Interestingly, bilirubin is a strong antioxidant and mild hyperbilirubinemia may have a protective effect against ischemic cardiovascular disease and cancer (Wang, Chowdhury J & Chowdhury N, 2006). In fact, a recent study looking at the history of colorectal cancer done on a large population reported the odds ratios to be reduced to 0.295 in men and 0.186 in women per 1 mg/dl increment in serum bilirubin levels (Wang, Chowdhury J & Chowdhury N, 2006). Furthermore, an inverse relationship between serum bilirubin levels and cancer mortality has also been reported (Wang, Chowdhury J & Chowdhury N, 2006). However, these findings do not suggest a direct cause-and-effect relationship and more research needs to be done in this area. | ||
