Differences
This shows you the differences between two versions of the page.
| Both sides previous revision Previous revision Next revision | Previous revision | ||
|
group_5_presentation_1_-_schizophrenia [2018/02/01 23:57] colettj |
group_5_presentation_1_-_schizophrenia [2018/02/02 15:09] (current) bhattvj [References] |
||
|---|---|---|---|
| Line 44: | Line 44: | ||
| ==== Etiology ==== | ==== Etiology ==== | ||
| - | Through the complex diagnosis of schizophrenia, the causes are not entirely known as to why one would directly be linked to the disorder. Genes and environment have been attributed to a probable cause as 10% of individuals who have a first-degree relative with the individual with schizophrenia. In the case of twins, the likelihood increases to a range from 10-65%. Through research it is shown that schizophrenia is not linked to a single gene in the biology thereby leading into the complexity of the disorder. This leads into the argument of genetic changes such as mutations as a cause for the illness. Other causes include pregnancy and birth complications such as low birth weight, premature labour and asphyxia during birth. | + | Through the complex diagnosis of schizophrenia, the causes are not entirely known as to why one would directly be linked to the disorder. Genes and environment have been attributed to a probable cause as 10% of individuals who have a first-degree relative with the individual with schizophrenia. In the case of twins, the likelihood increases to a range from 10-65%. Through research it is shown that schizophrenia is not linked to a single gene in the biology thereby leading into the complexity of the disorder. Many genes act synergistically resulting in changed neurotransmitter interactions (Harrison, 2014). Genetic risk for schizophrenia comes from changes in the DNA sequences, more specifically single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). Several loci have been observed including CACNA1C which is a L- type calcium channel, DRD2, the dopamine D2 receptor, GRIA1, an AMPA receptor subunit and GRIN2A, a NMDA receptor subunit to name a few (Harrison, 2014). This leads into the argument of genetic changes such as mutations as a cause for the illness. Other causes include pregnancy and birth complications such as low birth weight, premature labour and asphyxia during birth. |
| Line 100: | Line 100: | ||
| While treatment through medication has been relatively successful at relieving the burden of positive symptoms, not much is known about this condition. Researchers emphasize the importance of first understanding the pathophysiology, then attempting to find the solution. It is believed that both genetics and environment play a role in developing this condition, as well as symptom severity, and as a result, more funding should be directed into this field (van Os, Rutten & Poulton, 2008). Although our progress in this disease appears to be superficial, physicians and researchers both believe that more effective treatments are in the near future. Through discoveries, not only will schizophrenia be better managed, but also other mental conditions - the once “black box” will be more understood. | While treatment through medication has been relatively successful at relieving the burden of positive symptoms, not much is known about this condition. Researchers emphasize the importance of first understanding the pathophysiology, then attempting to find the solution. It is believed that both genetics and environment play a role in developing this condition, as well as symptom severity, and as a result, more funding should be directed into this field (van Os, Rutten & Poulton, 2008). Although our progress in this disease appears to be superficial, physicians and researchers both believe that more effective treatments are in the near future. Through discoveries, not only will schizophrenia be better managed, but also other mental conditions - the once “black box” will be more understood. | ||
| + | {{:schizophrenia.pptx|}} | ||
| ======References====== | ======References====== | ||
| Line 123: | Line 124: | ||
| Gong, Q., Lui, S., & Sweeney, J. A. (2015). A selective review of cerebral abnormalities in patients with first-episode schizophrenia before and after treatment. American Journal of Psychiatry, 173(3), 232-243. | Gong, Q., Lui, S., & Sweeney, J. A. (2015). A selective review of cerebral abnormalities in patients with first-episode schizophrenia before and after treatment. American Journal of Psychiatry, 173(3), 232-243. | ||
| + | |||
| + | Harrison, P. (2014). Recent genetic findings in schizophrenia and their therapeutic relevance. Journal Of Psychopharmacology, 29(2), 85-96. | ||
| Healthwise Staff (2011). Second-Generation Antipsychotics for Treating Schizophrenia. Michigan Medicine. | Healthwise Staff (2011). Second-Generation Antipsychotics for Treating Schizophrenia. Michigan Medicine. | ||
