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group_4_presentation_3_-_obesity [2019/04/02 02:46]
bustardz [Linked Diseases]
group_4_presentation_3_-_obesity [2019/04/05 17:21] (current)
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 Dependent on if you are a child or adult, doctors use calculations to measure the BMI of the individual to diagnose obesity. The body mass index is a calculation that uses an individual’s weight and height. The formula is BMI = weight (kg) / height (m^2). The body mass index is used to determine whether the individual is underweight,​ healthy weight, overweight, or obese. Looking at the chart provided, children are considered underweight if their BMI is under the 5th percentile, and adults are considered underweight if their BMI is under 18.5 (National Heart, Lung, and Blood Institute, 2019). Children are considered obese if their BMI is the 95th percentile or above, and adults are considered overweight if their BMI is 30 or above (National Heart, Lung, and Blood Institute, 2019). Dependent on if you are a child or adult, doctors use calculations to measure the BMI of the individual to diagnose obesity. The body mass index is a calculation that uses an individual’s weight and height. The formula is BMI = weight (kg) / height (m^2). The body mass index is used to determine whether the individual is underweight,​ healthy weight, overweight, or obese. Looking at the chart provided, children are considered underweight if their BMI is under the 5th percentile, and adults are considered underweight if their BMI is under 18.5 (National Heart, Lung, and Blood Institute, 2019). Children are considered obese if their BMI is the 95th percentile or above, and adults are considered overweight if their BMI is 30 or above (National Heart, Lung, and Blood Institute, 2019).
 +
 +
 +{{:​bmi_table_children_and_adults.jpg?​500| }}
  
 === Physical and Medical Examination ​  === === Physical and Medical Examination ​  ===
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 Obesity has many risk factors that can be changed and many risk factors that cannot be changed. The factors that can be changed are environments and unhealthy lifestyle habits (National Heart, Lung, and Blood Institute, 2019). The factors that cannot be changed are age, sex, genetics, family history, and ethnicity (National Heart, Lung, and Blood Institute, 2019). Changing your unhealthy lifestyle habit into a healthy lifestyle can decrease the risk of becoming obese. ​ Obesity has many risk factors that can be changed and many risk factors that cannot be changed. The factors that can be changed are environments and unhealthy lifestyle habits (National Heart, Lung, and Blood Institute, 2019). The factors that cannot be changed are age, sex, genetics, family history, and ethnicity (National Heart, Lung, and Blood Institute, 2019). Changing your unhealthy lifestyle habit into a healthy lifestyle can decrease the risk of becoming obese. ​
  
 +===== Pathophysiology =====
 +In the past decade, a bulk of research regarding obesity has looked into its regulation since it is tied with molecular regulation of appetite, ultimately affecting energy homeostasis. With that said, during nutrient deprived states, like starvation, a plethora of stored fat is necessary in order for the individual’s survival. On the other hand, during prolonged abundance of food in the body, there is excessive storage of fats that result in obesity, due to the body’s extremely efficiency fat storage system (Spiegelman & Flier, 2001). The excessive storage of fat that creates obesity will stimulate an enhanced sympathetic state, which will eventually lead to release of excessive fatty acids from enhanced lipolysis. Subsequently,​ this excessive release of fatty acids are free in the body and can stimulate lipotoxicity because there is oxidative stress to the endoplasmic reticulum (ER) and mitochondria of cells that is created by the lipids and their metabolites. Not only does this phenomenon affect adipose tissues, but also non-adipose tissues as well, which is why obesity extends its pathophysiology to many organs like the kidneys, liver and pancreas as well as in metabolic syndrome (Evans, Barish, & Wang, 2004). In addition, fatty free acids that are secreted from excessively stored triglyceride also aid in the inhibition of lipogenesis which prevents proper clearance of serum triglyceride levels. As a result, the improper clearance of triglyceride contributes to hypertriglyceridemia which means there are a high levels of triglycerides on the blood serum. One consequence of hypertriglyceridemia is the release of fatty acids by endothelial lipoprotein lipase within elevated beta lipoproteins. With that said, there is insulin-receptor dysfunction due to this elevation and this dysfunctional state creates hyperglycemia and increased glucose production in the liver. Furthermore,​ one other effect from the lipotoxicity caused by excessive fatty acids is a decrease in the secretion of insulin from the pancreas, resulting in beta-cell exhaustion (Redinger, 2007).
  
-===== Evolutionary Basis of Obesity =====+{{ :​pasted_image_0.png?​direct |}}
  
-<box 55% round right | > {{ ::​prevalence.png?​nolink|}} </box| Figure 3: This map displays a country-by-country look at adult obesity prevalence in 2008. https://​www.hsph.harvard.edu/​obesity-prevention-source/​map-of-global-obesity-trends/​ > 
  
-===== Obesity and Gender ===== 
  
-<box 50% round | > {{ :​obesity_scale.png |}} </box| Figure 2: Illustration classifying the different BMI classifications. https://​2o42f91vxth73xagf92zhot2-wpengine.netdna-ssl.com/​blog/​wp-content/​uploads/​sites/​4/​2017/​07/​Chart.jpg ​ >+===== Linked Diseases =====
  
 +When an individual suffers from obesity, there are many increased health risks for certain diseases, making them more susceptible. These include sleep apnea, type 2 diabetes mellitus, coronary heart disease, ​ gall stones, cancer, gout and arthritis, to name some. However, the three leading diseases linked to obesity are type 2 diabetes, coronary heart disease and cancer (Redinger, 2007).
  
-===== Pathophysiology ===== +Since obesity is accompanied by inflammation in many of the tissues and organs within ​the body, a major risk factor ​of obesity includes cancer ​in various forms like breastcolonrenal and prostate, to name a fewIn factobesity was found to account for 20 to 33% of breast, esophageal, endothelial ​and kidney cancerThe increased risk of cancer ​is brought about through ​many different mechanisms seen in the pathophysiology ​of obesityFor instance, the risk of colon cancer is increased due to the combined effects ​of diabetes, insulin ​resistance ​and increased ​BMI because ​the excessive fatty acids exert lipotoxicity leading to decreased ​insulin ​secretion. Additionally,​ studies have observed an association between ​the increased leptin levels that occur in obese individuals and cancer. Thuscancer risk increased as these leptin levels contribute to cellular proliferation,​ dedifferentiation and inhibition of apoptosis ​in cancer ​(Redinger, 2007).
-In the past decade, a bulk of research regarding ​obesity ​has looked into its regulation since it is tied with molecular regulation ​of appetite, ultimately affecting energy homeostasis. With that said, during nutrient deprived states, like starvation, a plethora of stored fat is necessary in order for the individual’s survival. On the other hand, during prolonged abundance of food in the body, there is excessive storage ​of fats that result ​in obesitydue to the body’s extremely efficiency fat storage system (Spiegelman & Flier2001). The excessive storage of fat that creates obesity will stimulate an enhanced sympathetic statewhich will eventually lead to release of excessive fatty acids from enhanced lipolysisSubsequentlythis excessive release of fatty acids are free in the body and can stimulate lipotoxicity because there is oxidative stress ​to the endoplasmic reticulum (ER) and mitochondria ​of cells that is created by the lipids ​and their metabolitesNot only does this phenomenon affect adipose tissues, but also non-adipose tissues as well, which is why obesity extends its pathophysiology to many organs like the kidneys, liver and pancreas as well as in metabolic syndrome (Evans, Barish, & Wang, 2004). In addition, fatty free acids that are secreted from excessively stored triglyceride also aid in the inhibition ​of lipogenesis which prevents proper clearance of serum triglyceride levelsAs a result, the improper clearance ​of triglyceride contributes ​to hypertriglyceridemia which means there are a high levels of triglycerides on the blood serum. One consequence ​of hypertriglyceridemia is the release of fatty acids by endothelial lipoprotein lipase within elevated beta lipoproteins. With that saidthere is insulin-receptor dysfunction due to this elevation and this dysfunctional state creates hyperglycemia ​and increased ​glucose production in the liver. Furthermore,​ one other effect from the lipotoxicity caused by excessive fatty acids is a decrease in the secretion of insulin ​from the pancreasresulting ​in beta-cell exhaustion ​(Redinger, 2007).+
  
 +Another disease that is closely linked to obesity is type 2 diabetes mellitus, due to insulin-receptor dysfunction and beta-cell exhaustion from elevated beta lipoproteins,​ as well as progressive insulin resistance. Since both insulin resistance and insulin-receptor dysfunction occur early in obese individuals,​ they progressively worsen overtime which ultimately lead to type 2 diabetes (Golay & Ybarra, 2005). One key factor that contributes to the onset of diabetes and insulin resistance in obese individuals is tumor necrosis factor alpha (TNF-alpha),​ which is a pro-inflammatory adipokine. With that said, increased secretion of TNF-alpha is observed with higher total body-fat mass individuals and it enhances inflammation in fatty livers and fat depots in other locations of the body, like the pancreas. Through interference with insulin receptor tyrosine kinase activity in both fat and muscle tissues, TNF-alpha causes insulin resistance and dysfunction and abnormalities of the pancreatic insulin receptors, as seen in multiple mice studies. Thus, leading to type 2 diabetes (Hotamisligil & Spiegelman, 1994).
  
-===== Linked Diseases =====+Lastly, individuals whom suffer with obesity are at major risk for development and progression of sleep apnea. In fact, sleep apnea is twice as prevalent in obese adults compared to normal-weight adults. Additionally,​ within obese children sleep apnea is 6 times as prevalent than in normal-weighted children. The link between obesity and sleep apnea is very complex, however evidence from studies show that there is a correlation that is present. With that said, possibility for obesity to worsen sleep apnea occurs due to fat deposition at specific sites in the body. For instance, there is fat deposition within tissues that surround the upper respiratory tract and trachea which makes an individual more vulnerable to sleep apnea. Moreover, there are also fat deposits around the thorax which reduce chest compliance, increase oxygen demand and reduce the volume of air present in the lungs when exhaling passively (Romero-Corral et al., 2010).
  
-When an individual suffers from obesity, there are many increased health risks for certain diseases, making them more susceptible. These include sleep apnea, type 2 diabetes mellitus, coronary heart disease, ​ gall stones, cancer, gout and arthritis, to name some. However, the three leading diseases linked to obesity are type 2 diabetes, coronary heart disease and cancer.+===== Prevention =====
  
-diabetes--add from word doc+In order to prevent obesity, it is important to eat and drink according to nutritional needs, exercise regularly, and monitor weight (Wirth, Wabitsch, & Hauner, 2014). Along with this, it is recommended that individuals consume foods with a low energy density as they often have a high water and fibre content (Wirth et al., 2014). Some examples include foods containing whole grains, fruits, and vegetables. In order to eat healthy, it is also recommended that the consumption of sugary drinks, alcohol, and fast food be reduced as they have a high fat and sugar content (Sayon-Orea, Martinez-Gonzalez, & Bes-Rastrollo,​ 2011). Other drinks such as fruits juices are also sweetened, high in sugar, and are not filling, which may cause an individual to consume greater quantities (Vartanian, Schwartz, & Brownell, 2007). In addition to consuming nutritious foods, living an active lifestyle can also prevent obesity. Periods of sitting should be reduced and individuals should engage in activities that promote weight loss (Wirth et al., 2014). A study by Donnelly et al. (2009) found that weight loss goals are best accomplished through endurance-focused exercise where large muscle groups are used for over 2 hours per week. With a combination of exercise and monitoring what is consumed, the risk of obesity can be reduced or prevented. ​
  
-cancer --add from word doc+===== Treatment =====
  
-cardiac problems ​-- add from word doc +Treatment for obesity depends on the individual’s BMI and body fat distribution,​ an assessment of risk factors, the presence of existing medical conditions, and the patient’s preferences (Wirth et al., 2014). ​ If an individual is seeking treatment, there are often indicators that can assess whether it is needed (Wirth et al., 2014). For one if an individual has a BMI that is equal to, or greater than 30 kg/m2  , then they are considered to be obese. If an individual’s BMI is between 25 and 30 kg/m2, then they are considered to be overweight but treatment would be recommended if this were also accompanied by other factors. These factors include other health impairments related to weight gain such as type 2 diabetes or hypertension,​ psychosocial stress, and abdominal obesity. More specifically,​ in seeking treatment, the long-term impacts of cardiovascular risk factors also need to be taken into account (Lawlor & Chaturvedi, 2006). This includes risk factors such as dyslipidaemia,​ hypertension,​ and insulin resistance. Along with this, disease outcomes such as diabetes, cardiovascular disease, and osteoporosis also need to be assessed.  
-===== Treatments ​=====+ 
 +=== Goals for Treatment ​  === 
 + 
 +Prior to treatment, it can be beneficial to set goals in order to see desirable outcomes and maintain the results. For example, individuals with a BMI between 25 and 35 kg/m2 should aim to lose over 5% of their initial weight (Wirth et al., 2014). For individuals with a BMI greater than 35 kg/m2, they should aim to lose over 10% of their initial weight. Other goals for treatment should be to decrease the risk factors that can lead to obesity and any diseases associated with it, reduce the risk of early death, prevent early retirement as a result of a decline in health, improve quality of life, and improve psychosocial health (Wirth et al., 2014).  
 + 
 +===== Forms of Treatment ===== 
 + 
 +=== Diets   === 
 + 
 +For diets, recommendations are personal according to the risk profile of the patient and their goals (Wirth et al., 2014). Diet plans are only effective if the patient complies with the lifestyle changes and recommendations. Diet plans can also be offered through diet therapy, where nutritional counselling is often received along with a medical management program. This can occur individually or in groups, but research has shown that group sessions can be more effective (Wirth et al., 2014). Within these sessions, diet recommendations can consist of strategies to reduce fat consumption,​ carbohydrate consumption or both. Research has looked at many effects of weight loss interventions in adults with obesity (Wirth et al., 2014). It was found that very low energy density diets consisting of less than 800 kcal/day, resulted in weight loss with about 15-25% of initial weight lost over a short period for individuals who completed a program. However, there are downsides to such programs as they can be expensive, and have a high chance of regaining 50% of the lost weight. In addition, there are many programs available over the internet, but it was found that many of these did not show weight loss results (Wirth et al., 2014). Other diets that have shown to be effective are low fat diets. They have positive effects on blood pressure and dyslipidaemia for obese individuals (Lawlor & Chaturvedi, 2006). 
 + 
 +=== Weight Loss Drugs   === 
 + 
 +Weight loss drugs are only recommended for use along with other interventions such as exercise, diet and behavioural therapy. One common type is Orlistat (Wirth et al., 2014). This is a gastrointestinal lipase inhibitor and aids in reducing fat absorption. It is recommended for individuals with a BMI over 28, or if there is a presence of other risk factors or co-morbidities. It can also be used if other basic programs for weight loss have not been effective. GLP-1 mimetics and SGLT2 inhibitors can also be used but are recommended for individuals with a BMI over 30, or if they have type 2 diabetes. GLP-1 regulates insulin and digestion and works to reduce appetite, while SGLT2 reduced glucose levels in the body. Furthermore,​ drugs such as diuretics, amphetamines,​ human chorionic gonadotropin (HCG), thyroxine, testosterone,​ and growth hormones are not recommended because their benefits don’t always outweigh the risks (Wirth et al., 2014).  
 + 
 +=== Physical Exercise ​  === 
 + 
 +Exercising daily or during free time can decrease risk factors and obesity associated disease while improving weight loss (Lawlor & Chaturvedi, 2006). It is recommended that individuals engage in over 150 minutes of exercise per week along with monitoring their caloric intake for optimal results. Research also shows that strength training alone is not effective, and that working out using large muscle groups, with moderate to high intensity is more beneficial (Wirth et al., 2014). Overall, there is great health value associated with an increase in exercise besides just weight loss as overall health can also be improved.  
 + 
 +=== Behaviour Modification and Behavioural Therapy ​  === 
 + 
 +This form of treatment works to implement lifestyle changes. This therapy is often a program for weight reduction and can occur in a group setting or individually. It mainly focuses on lifestyle changes such as nutrition and exercise, and methods to improve them (Wirth et al., 2014). In cases where symptoms are more severe such as depression or eating disorders, psychiatrists and psychotherapists could be involved. In this form of treatment, common strategies are used that can be adjusted depending on the individual case and expectations. Some of these strategies consist of: 
 +  * Social support 
 +  * Observing progress and behaviour (exercise, eating habits, and body weight) 
 +  * Controlled, flexible, exercise and eating rather than rigorous control 
 +  * Controlling stimuli that may trigger eating  
 +  * Strategies to deal with any return of weight gain 
 +  * Cognitive reconstruction (modifying thoughts that are dysfunctional) 
 +  * Training for problem-solving  
 +  * Training for assertiveness or social competence 
 +  * Strategies for reinforcement (rewarding any changes that are observed) 
 +  * Prevention strategies for relapse  
 + 
 +=== Surgical Interventions ​  === 
 + 
 +Surgery is often used for cases of extreme obesity or if all other conservative treatment methods are not successful (Wirth et al., 2014). It can also be recommended as a primary treatment before trying conservative methods if it is believed that they will have no effect. Surgery is often used for three different grades of obesity that are characterized by BMI (Wirth et al., 2014). Grade I is for individuals with a BMI between 30 and 35, with type 2 diabetes. Grade II obesity categorizes individuals with a BMI between 35 and 40 with significant co-morbidities,​ while grade III obesity means the individual has a BMI over 40. Different types of surgery can also be used such as sleeve gastrectomy (a), gastric banding (b), and gastric bypass (c in the image below). Overall, surgery is more effective in reducing body fat, decreasing obesity related disease, and decreasing mortality risk due to the large impact it can have compared to other treatments (Lawlor & Chaturvedi, 2006). To put this into perspective,​ one study found that in a one to two year time span, individuals were able to lose 20-40kg through bariatric surgery, 4-6kg through dietary therapy, and only 2-3 by exercise therapy (Lawlor & Chaturvedi, 2006). However, these results would vary depending on the individual, their dedication, and maintenance of their health goals.  
 + 
 +{{::​surgery.png?​200|}}
  
 ===== Conclusion ===== ===== Conclusion =====
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 Obesity is a problem that is impacting many individuals around the world specifically in western countries. This disease can be inherited by environmental or genetic factors. With the consumption of many fats, and high caloric meals the individual can develop obesity. It is critical that the individual burns more calories than they consume. Although, this may not always be the reason but, research has shown that if a person has low to none exercise levels, he or she has a high possibility to develop obesity. Medicines such as insulin and thiazolidinediones (TZDs) can also result in excessive weight gain (OAC, n.d.). Using the body mass index, we can determine whether the person is obese or not. If the child is 95th percentile or over they are considered to be obese and if the adult is 30 or above he/she is obese. To prevent obesity from happening it is critical that to maintain a healthy lifestyle and ask doctors about what medication can result in weight gain.  Obesity is a problem that is impacting many individuals around the world specifically in western countries. This disease can be inherited by environmental or genetic factors. With the consumption of many fats, and high caloric meals the individual can develop obesity. It is critical that the individual burns more calories than they consume. Although, this may not always be the reason but, research has shown that if a person has low to none exercise levels, he or she has a high possibility to develop obesity. Medicines such as insulin and thiazolidinediones (TZDs) can also result in excessive weight gain (OAC, n.d.). Using the body mass index, we can determine whether the person is obese or not. If the child is 95th percentile or over they are considered to be obese and if the adult is 30 or above he/she is obese. To prevent obesity from happening it is critical that to maintain a healthy lifestyle and ask doctors about what medication can result in weight gain. 
 ===== References ===== ===== References =====
 +
 +Donnelly, J. E., Blair, S. N., Jakicic, J. M., Manore, M. M., Rankin, J. W., & Smith, B. K. (2009). Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Medicine & Science in Sports & Exercise, 41(2), 459-471.
  
 Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004). PPARs and the complex journey to obesity. Nature Medicine, 10(4), 355–361. https://​doi.org/​10.1038/​nm1025 Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004). PPARs and the complex journey to obesity. Nature Medicine, 10(4), 355–361. https://​doi.org/​10.1038/​nm1025
  
 +Golay, A., & Ybarra, J. (2005). Link between obesity and type 2 diabetes. Best Practice & Research Clinical Endocrinology & Metabolism, 19(4), 649–663. https://​doi.org/​10.1016/​j.beem.2005.07.010
  
-1. National HeartLungand Blood Institute. (2019). Overweight and Obesity. [online] Available athttps://​www.nhlbi.nih.gov/​health-topics/​overweight-and-obesity ​[Accessed 31 Mar2019].+Hotamisligil,​ G. S., & SpiegelmanB. M. (1994). Tumor necrosis factor alphaa key component of the obesity-diabetes linkDiabetes, 43(11), 1271–1278.
  
-2.      Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., BalesVS., & MarksJ. S. (2003). Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001JAMA289(1), 7679. https://​doi.org/​10.1001/jama.289.1.76+KatzmarzykPT., & MasonC. (2006). Prevalence of class III and III obesity in CanadaCMAJ : Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne174(2), 1567. https://​doi.org/​10.1503/cmaj.050806
  
-3.      KatzmarzykPT., & MasonC. (2006). ​Prevalence ​of class I, II and III obesity ​in Canada. CMAJ : Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne, 174(2), 156–7. https://​doi.org/​10.1503/​cmaj.050806+LawlorDA., & ChaturvediN. (2006). ​Treatment and prevention ​of obesity—are there critical periods for intervention?​.
  
-4      ​Obesity in Canada - Obesity Canada. (n.d.). Retrieved April 1, 2019, from https://​obesitycanada.ca/​obesity-in-canada/​+Mokdad, AH., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003). Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001. JAMA, 289(1), 76–79. https://​doi.org/​10.1001/​jama.289.1.76 
 + 
 +National Heart, Lung, and Blood Institute. (2019). Overweight and Obesity. [online] Available at: https://​www.nhlbi.nih.gov/​health-topics/​overweight-and-obesity [Accessed 31 Mar. 2019]. 
 + 
 +Obesity in Canada - Obesity Canada. (n.d.). Retrieved April 1, 2019, from https://​obesitycanada.ca/​obesity-in-canada/​
  
 Redinger, R. N. (2007). The Pathophysiology of Obesity and Its Clinical Manifestations. Gastroenterology & Hepatology, 3(11), 856–863. Retrieved from https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3104148/​ Redinger, R. N. (2007). The Pathophysiology of Obesity and Its Clinical Manifestations. Gastroenterology & Hepatology, 3(11), 856–863. Retrieved from https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3104148/​
 +
 +Romero-Corral,​ A., Caples, S. M., Lopez-Jimenez,​ F., & Somers, V. K. (2010). Interactions Between Obesity and Obstructive Sleep Apnea. Chest, 137(3), 711–719. https://​doi.org/​10.1378/​chest.09-0360
 +
 +Sayon-Orea, C., Martinez-Gonzalez,​ M. A., & Bes-Rastrollo,​ M. (2011). Alcohol consumption and body weight: a systematic review. Nutrition reviews, 69(8), 419-431.
  
 Spiegelman, B. M., & Flier, J. S. (2001). Obesity and the regulation of energy balance. Cell, 104(4), 531–543. Spiegelman, B. M., & Flier, J. S. (2001). Obesity and the regulation of energy balance. Cell, 104(4), 531–543.
  
 +Vartanian, L. R., Schwartz, M. B., & Brownell, K. D. (2007). Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. American journal of public health, 97(4), 667-675.
  
 +Wirth, A., Wabitsch, M., & Hauner, H. (2014). The Prevention and Treatment of Obesity. Deutsches Aerzteblatt Online. doi:​10.3238/​arztebl.2014.0705
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