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group_4_presentation_1_-_weight_loss_supplements [2019/01/29 23:07] bustardz |
group_4_presentation_1_-_weight_loss_supplements [2019/02/01 23:05] (current) dhaliwaa [References] |
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| There are two main methods by which Garcinia Cambogia can facilitate weight loss. It can either block fat production or reduce appetite. | There are two main methods by which Garcinia Cambogia can facilitate weight loss. It can either block fat production or reduce appetite. | ||
| - | Hydroxcytric acid, the principal ingredient in Garcinia supplements, is a significant inhibitor of ATP. It specifically acts on ATP citrate lyase which is the primary enzyme that generates acetyl CoA from citrate in the cytosol of mammalian cells (Watson et al., 1969). Additionally, studies show that Hydroxcytric acid inhibits fatty acid synthesis in the liver through a series of biomechanical pathways. In summary, HCA inhibits lipogenesis by inhibiting ACLY, SREBP-1c and FAS expression, and accelerates lipolysis through amplifying HL activity and PPARα expression (Han, 2016). The following figure summarizes the methods by which hydroxycytric acid can reduce fat accumulation. | + | Hydroxycitric acid, the principal ingredient in Garcinia supplements, is a significant inhibitor of ATP. It specifically acts on ATP citrate lyase which is the primary enzyme that generates acetyl CoA from citrate in the cytosol of mammalian cells (Watson et al., 1969). Additionally, studies show that hydroxycitric acid inhibits fatty acid synthesis in the liver through a series of biomechanical pathways. In summary, HCA inhibits lipogenesis by inhibiting ACLY, SREBP-1c and FAS expression, and accelerates lipolysis through amplifying HL activity and PPARα expression (Han, 2016). The following figure summarizes the methods by which hydroxycitric acid can reduce fat accumulation. |
| - | The exact mechanism by which hydroxcytric acid suppresses appetite is unclear, however, rat studies suggest that Garcinia Cambodia can raise levels of serotonin, an appetite suppressant (Ohia et al., 2001). Researchers have shown that hydroxcytric acid can increase the release and availability of serotonin in the synaptic cleft in cells of the rat cortex. Serotonin is known to regulate eating behavior and appetite control by which higher levels tend to reduce appetite (Ohia et al., 2001). | + | The exact mechanism by which hydroxycitric acid suppresses appetite is unclear, however, rat studies suggest that Garcinia Cambodia can raise levels of serotonin, an appetite suppressant (Ohia et al., 2001). Researchers have shown that hydroxycitric acid can increase the release and availability of serotonin in the synaptic cleft in cells of the rat cortex. Serotonin is known to regulate eating behavior and appetite control by which higher levels tend to reduce appetite (Ohia et al., 2001). |
| ===== Clinical Studies ===== | ===== Clinical Studies ===== | ||
| Various studies in animals support the use of hydroxcitrate as a supplement (Rao & Sakariah, 1988). In a particular study, Albino rats were fed a lipogenic diet with and without the addition of (−) hydroxycitrate for 15 days. After sacrificing the rats, the blood, liver and epididymal fat contents were measured and subsequently analyzed. Results indicated that rats who consumed hydroxycitrate had a significant reduction in food consumption, epididymal fat, serum triglyceride and an overall decrease in the feed efficiency ratio (Rao & Sakariah, 1988). | Various studies in animals support the use of hydroxcitrate as a supplement (Rao & Sakariah, 1988). In a particular study, Albino rats were fed a lipogenic diet with and without the addition of (−) hydroxycitrate for 15 days. After sacrificing the rats, the blood, liver and epididymal fat contents were measured and subsequently analyzed. Results indicated that rats who consumed hydroxycitrate had a significant reduction in food consumption, epididymal fat, serum triglyceride and an overall decrease in the feed efficiency ratio (Rao & Sakariah, 1988). | ||
| - | Some human trials also support the efficacy of hydroxcytric acid in reducing weight and fat (Preuss et al., 2004). A double-blind, placebo-controlled, human trial was conducted in thirty obese individuals for eight weeks in India. Results indicate that body weight and body mass index decline by 6.3% in the HCA group. Furthermore, total cholesterol and triglyceride levels were reduced by 6.3% and 8.6% while food intake was reduced by 4%. Urine analysis revealed a 125-258% increase in excretion of fat metabolites such as acetaldehyde, formaldehyde and acetone. Thus, it is evident that fat accumulation and weight loss can indeed occur by consuming HCA. Additionally, the study also noted that test participants had a 40% increase in serotonin, an appetite suppressant, which further provides support for the reduction in appetite (Preuss et al., 2004). | + | Some human trials also support the efficacy of hydroxycitric acid in reducing weight and fat (Preuss et al., 2004). A double-blind, placebo-controlled, human trial was conducted in thirty obese individuals for eight weeks in India. Results indicate that body weight and body mass index decline by 6.3% in the HCA group. Furthermore, total cholesterol and triglyceride levels were reduced by 6.3% and 8.6% while food intake was reduced by 4%. Urine analysis revealed a 125-258% increase in excretion of fat metabolites such as acetaldehyde, formaldehyde and acetone. Thus, it is evident that fat accumulation and weight loss can indeed occur by consuming HCA. Additionally, the study also noted that test participants had a 40% increase in serotonin, an appetite suppressant, which further provides support for the reduction in appetite (Preuss et al., 2004). |
| ===== Side effects & recommended dosage: ===== | ===== Side effects & recommended dosage: ===== | ||
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| ====== Conclusion ====== | ====== Conclusion ====== | ||
| - | When selecting and determining the efficacy of fat loss supplements it is important to examine the various ingredients listed on the label. The supplement industry is a for-profit business and oftentimes, there may be unsubstantiated and exaggerated claims of weight loss and it is therefore more crucial to look at relevant scientific studies to validate such statements. Furthermore, it is also imperative to critically analyze the studies that were performed and determine whether it the results can be applicable to human dosages. For example, studies done on raspberry ketones may show some promise in rodents, but has no evidence of efficacy in humans. Moreover, when converting rodent to human dosage, the required supplementation becomes astronomically high. Other critical variables regarding dietary supplements also include safety and toxicity. It is strongly advised for individuals looking at fat loss supplements to do their own extensive research on individual compounds and risks involved. | + | |
| + | The best way to lose weight is to eat healthily and exercise! Although some weight loss supplements are successful, many of them can have detrimental side effects and injure your health. There is a need for further research of these supplements as many new discoveries are made each year and links to new diseases are becoming more prevalent. | ||
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| + | Overall, weight loss supplements have not promised significant results in comparison to traditional conventions such as diet and exercise. People often opt for weight loss supplements due to the desire for quick results, their availability without prescription, the lack of physical demand, and many more perceived benefits due to inflated advertisement claims. | ||
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| + | In terms of the future of weight loss supplements, new drugs such as Lorcaserin have come out on the market in recent years, and have been considered safe for use (“A new drug,” 2018). This pill has not shown to increase the risk of cardiovascular disease as a side effect, and has demonstrated sustainable weight loss outcomes (Bohula et al., 2018). Whereas, popular supplements such as Garcinia Cambogia, Hydroxycut, and Synephrine, which have been available for years, have all demonstrated considerable side effects. However, with Lorcaserin, the average participant only lost about nine pounds over a four-year period, which has prompted health professionals to question whether it’s worth it (“A new drug,” 2018). It is also expensive, and can cost users almost $9,000 USD over this period of use (“A new drug,” 2018). Additionally, similar to other supplements on the market, there is not enough research to show that it won’t cause health problems in the future. The only drugs approved for weight-loss in Canada are Saxenda, Xenical, and Contrave, but these do not allow patients to learn the benefits of healthy habits and appropriate diets (“A new drug,” 2018). Therefore, the recommended, and most effective approach to weight loss is a combination of increased exercise and limited calorie intake (Boucher, Shafer, & Chaffin, 2001). | ||
| ====== References ====== | ====== References ====== | ||
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| [25] Gunnars, K. (2019). Top 12 Biggest Myths About Weight Loss. Retrieved from https://www.healthline.com/nutrition/top-12-biggest-myths-about-weight-loss#section11 | [25] Gunnars, K. (2019). Top 12 Biggest Myths About Weight Loss. Retrieved from https://www.healthline.com/nutrition/top-12-biggest-myths-about-weight-loss#section11 | ||
| + | [26] Beware of Products Promising Miracle Weight Loss. (2018). Retrieved from | ||
| + | https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm246742.htm | ||
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| + | [27] Saper, R. B., Eisenberg, D. M., & Phillips, R. S. (2004). Common dietary supplements for | ||
| + | weight loss. American family physician, 70, 1731-1740. | ||
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| + | [28] Boucher, J. L., Shafer, K. J., & Chaffin, J. A. (2001). Weight Loss, Diets, and Supplements: Does | ||
| + | Anything Work?. Diabetes Spectrum, 14(3), 169-175. | ||
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| + | [29] Studley, T. (2019). Different Types of Weight Loss Supplements. Retrieved from | ||
| + | https://expertratedreviews.com/different-types-of-weight-loss-supplements/ | ||
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| + | [30] Dietary Supplements for Weight Loss. (2017). Retrieved from | ||
| + | https://ods.od.nih.gov/factsheets/WeightLoss-Consumer/ | ||
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| + | [31] Pooyandjoo, M., Nouhi, M., Shab‐Bidar, S., Djafarian, K., & Olyaeemanesh, A. (2016). The | ||
| + | effect of (L‐) carnitine on weight loss in adults: a systematic review and meta‐analysis of randomized controlled trials. Obesity reviews, 17(10), 970-976. | ||
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| + | [32] A new drug is being called the ‘holy grail’ of weight-loss medicine. Is it true?. (2018). Retrieved from https://globalnews.ca/news/4414557/weight-loss-drug-approved/ | ||
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| + | [33] Bohula, E. A., Wiviott, S. D., McGuire, D. K., Inzucchi, S. E., Kuder, J., Im, K., ... & Garcia-Castillo, A. (2018). Cardiovascular safety of lorcaserin in overweight or obese patients. New England Journal of Medicine, 379(12), 1107-1117. | ||
