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--- group_1_presentation_3_-_physiological_effects_of_caffeine [2020/03/24 22:25]
dhanda1 [Introduction]
+++ group_1_presentation_3_-_physiological_effects_of_caffeine [2020/03/26 13:28] (current)
guos13
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 ====== Presentation Slides ======
+{{::lifesci_4m03_group1_caffeine.pptx|Caffeine Presentation}}
 ====== Introduction ======
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-**Figure : Change in self-reported anxiety based on the Visual Analog Scale (VAS) after exposure to different doses of caffeine.** Data represents mean peak change from pre-caffeine baseline in participants post-caffeine exposure. Only the the highest dose of caffeine (450mg) significantly increased ratings of anxiety (p-value<0.01). (Childs et al., 2008).
+**Figure 3: Change in self-reported anxiety based on the Visual Analog Scale (VAS) after exposure to different doses of caffeine.** Data represents mean peak change from pre-caffeine baseline in participants post-caffeine exposure. Only the the highest dose of caffeine (450mg) significantly increased ratings of anxiety (p-value<0.01). (Childs et al., 2008).
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-**Figure : Change in self-reported anxiety based on the Profile of Mood States (POMS) after exposure to placebo and 150mg of caffeine.** Between the three genotypic groups, only the 1976T/T groups reported significant increase in anxiety. (Alsene et al., 2003).
+**Figure 4: Change in self-reported anxiety based on the Profile of Mood States (POMS) after exposure to placebo and 150mg of caffeine.** Between the three genotypic groups, only the 1976T/T groups reported significant increase in anxiety. (Alsene et al., 2003).
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-**Figure : Change in self-reported anxiety based on the Visual Analog Scale (VAS) after exposure to placebo and 150mg of caffeine.** Between the three genotypic groups, only the 1976T/T groups reported significant increase in anxiety. (Alsene et al., 2003).
+**Figure 5: Change in self-reported anxiety based on the Visual Analog Scale (VAS) after exposure to placebo and 150mg of caffeine.** Between the three genotypic groups, only the 1976T/T groups reported significant increase in anxiety. (Alsene et al., 2003).
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 {{ :what-to-expect-from-caffeine-withdrawal-21844-v1-5c521bb246e0fb000180a7ec.png?nolink&500 |}}
-**Figure : Common symptoms resulting from cessation of caffeine.** Withdrawal from caffeine causes mild to clinically significant distress and impairment of daily functioning. Caffeine withdrawal symptoms begin around 12-24 hours after cessation of caffeine intake and reach maximum intensity 20-48 hours after abstinence (Schuh and Griffiths, 1997). Common symptoms include headaches, fatigue, decreased alertness, nausea and a negative mood.
+**Figure 6: Common symptoms resulting from cessation of caffeine.** Withdrawal from caffeine causes mild to clinically significant distress and impairment of daily functioning. Caffeine withdrawal symptoms begin around 12-24 hours after cessation of caffeine intake and reach maximum intensity 20-48 hours after abstinence (Schuh and Griffiths, 1997). Common symptoms include headaches, fatigue, decreased alertness, nausea and a negative mood.
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 ====== Conclusion ======
+From what we’ve seen in this wiki, there are so many processes affected by the consumption of caffeine. To put this into perspective, considering that this is the world’s most consumed stimulant, it is significantly impacting the lives of many on a daily basis! In terms of the digestive system, while it is a known laxative and diuretic, it has the potential to exert protective effects on the stomach from things like gastric cancer! Additionally, it aids on our body in glucose metabolism. However, due to its acidic nature and associated irritating effect on the mucosal layers of the esophagus and stomach, we see an increase in gastroesophageal reflux and heartburn. Essentially, we seem some pros and cons of caffeine in the context of our digestive system. Similarly, the cardiovascular system has potential to be impacted by caffeine consumption. Its acute effects involve an increase in blood pressure, but a decrease in heart rate. Intuitively speaking, that means chronic caffeine consumption can potentially result in hypertension. Aside from caffeine-induced anxiety, increased wakefulness when one is trying to sleep, and the withdrawal symptoms, we see that there can be positive effects of caffeine consumption. Despite all the information provided in this wiki, it is important to realise that much of the results are inconclusive, and more research needs to be conducted. As such, take everything with a grain of salt and try to remain informed when consuming caffeine!
 ====== References ======
+Alsene, K., Deckert, J., Sand, P., & de Wit, H. (2003). Association Between A2a Receptor Gene Polymorphisms and Caffeine-Induced Anxiety. Neuropsychopharmacology, 28(9), 1694-1702. doi: 10.1038/sj.npp.1300232
 Arendt, J. (2009). Managing jet lag: Some of the problems and possible new solutions. Sleep Medicine Reviews, 13(4), 249–256. doi: 10.1016/j.smrv.2008.07.011
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 Burke, T. M., Markwald, R. R., Mchill, A. W., Chinoy, E. D., Snider, J. A., Bessman, S. C., … Wright, K. P. (2015). Effects of caffeine on the human circadian clock in vivo and in vitro. Science Translational Medicine, 7(305). doi: 10.1126/scitranslmed.aac5125
+Childs, E., Hohoff, C., Deckert, J., Xu, K., Badner, J., & de Wit, H. (2008). Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety. Neuropsychopharmacology, 33(12), 2791-2800. doi: 10.1038/npp.2008.17
 Chrysant, S. G. (2017). The impact of coffee consumption on blood pressure, cardiovascular disease and diabetes mellitus. Expert Review of Cardiovascular Therapy, 15(3), 151–156. doi: 10.1080/14779072.2017.1287563
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 Eamudomkarn, N., Kietpeerakool, C., Kaewrudee, S., Jampathong, N., Ngamjarus, C., & Lumbiganon, P. (2018). Effect of postoperative coffee consumption on gastrointestinal function after abdominal surgery: A systematic review and meta-analysis of randomized controlled trials. Scientific reports, 8(1), 1-9.
+Fredholm, B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. (2000). Structure and function of adenosine receptors and their genes. Naunyn-Schmiedeberg's Archives Of Pharmacology, 362(4-5), 364-374. doi: 10.1007/s002100000313
 Gkegkes, I. D., Minis, E. E., & Iavazzo, C. (2020). Effect of Caffeine Intake on Postoperative Ileus: A Systematic Review and Meta-Analysis. Digestive surgery, 37(1), 22-31.
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 Sigmon, S. C., Herning, R. I., Better, W., Cadet, J. L., & Griffiths, R. R. (2009). Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects. Psychopharmacology, 204(4), 573-585.
+Snyder, S. H., & Sklar, P. (1984). Behavioral and molecular actions of caffeine: focus on adenosine. Journal of Psychiatric Research, 18(2), 91-106.
 Staack, A., Distelberg, B., Schlaifer, A., & Sabaté, J. (2017). Prospective study on the effects of regular and decaffeinated coffee on urinary symptoms in young and healthy volunteers. Neurourology and urodynamics, 36(2), 432-437.

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