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public:research 2024/03/23 00:45 public:research 2026/02/07 20:57 current
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==== Imaging in the Gastrointestinal Tract ("Google Streetview" of the Colon) ==== ==== Imaging in the Gastrointestinal Tract ("Google Streetview" of the Colon) ====
-In colonoscopy, it is important to monitor the progression or recurrence of suspected cancerous lesions (e.g., polyps). Because the colon is contractile and mobile, however, it is very difficult to relocate a lesion (e.g., a polyp) even during the same procedure. We are developing a novel 360 degree panoramic imaging method to build a map of colon lining, during colonoscopy, and use it to locate and track cancerous and pre-cancerous lesions. This research will make colon cancer screening and treatments more effective.  +In colonoscopy, it is important to monitor the progression or recurrence of suspected cancerous lesions (e.g., polyps). Because the colon is contractile and mobile, however, it is very difficult to relocate a lesion (e.g., a polyp) even during the same procedure. We are developing a novel 360 degree panoramic imaging method to build a map of colon lining, during colonoscopy, and use it to locate and track cancerous and pre-cancerous lesions. This research will make colon cancer screening and treatments more effective.  
 + 
 +A motion tracking device was previously developed to provide the accurate position, rotation, and velocity of the endoscope to be used in both upper and lower gastrointestinal procedures. It will help gastroenterologists during examination, diagnosis, treatments, and follow-ups to record precise location information during a procedure whether it is for determining the exact area for follow-ups, training doctors, or comparing the size of a tumour. In the current phase, this prototype design is being optimized using modern camera and imaging features as well as hardware and software design to produce a more efficient product that can be used in a clinical setting. The benefits of this design as compared to other solutions are the cost-effective, small-sized, real-time, and software based approach that can simplify the design and minimize the weight of the device. It is also placed externally on the endoscope and does not go inside the patient which allows for it to be removed or disposed. 
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**Publications:** **Publications:**
 +  * Jigar Lad, Erica Dao, Gabriella Gohla, Peter Lovrics, Qiyin Fang, Thomas J. Farrell, Michael J. Farquharson, "Time-Resolved Fluorescence and Diffuse Reflectance (TRF-DR) Spectroscopy for Heterogeneous Breast Tissue Classification and Tumor Margin Assessment," Journal of Biophotonics, 2026, 19(2):e70230. [[https://doi.org/10.1002/jbio.70230|doi: 10.1002/jbio.70230. PMID: 41622347; PMCID: PMC12862050]].
  * Zhaojun Nie, Shu-Chi Allison Yeh, Michelle LePalud, Fares Badr, Frances Tse, David Armstrong, Louis W. C. Liu, M. Jamal Deen, and Qiyin Fang, "Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra," Frontiers in Physiology, 11:339, 2020,  doi.org/10.3389/fphys.2020.00339| ([[https://doi.org/10.3389/fphys.2020.00339|open access online]])   * Zhaojun Nie, Shu-Chi Allison Yeh, Michelle LePalud, Fares Badr, Frances Tse, David Armstrong, Louis W. C. Liu, M. Jamal Deen, and Qiyin Fang, "Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra," Frontiers in Physiology, 11:339, 2020,  doi.org/10.3389/fphys.2020.00339| ([[https://doi.org/10.3389/fphys.2020.00339|open access online]])
  *  Le V. N. Du, Manser Myla, Gurm Sunny, Wagner Ben, Hayward Joseph E., Fang Qiyin, "Calibration of Spectral Imaging Devices With Oxygenation-Controlled Phantoms: Introducing a Simple Gel-Based Hemoglobin Model," Frontiers in Physics, 7: 192, 2019, DOI=10.3389/fphy.2019.00192  ([[https://www.frontiersin.org/article/10.3389/fphy.2019.00192|Open Access]])        *  Le V. N. Du, Manser Myla, Gurm Sunny, Wagner Ben, Hayward Joseph E., Fang Qiyin, "Calibration of Spectral Imaging Devices With Oxygenation-Controlled Phantoms: Introducing a Simple Gel-Based Hemoglobin Model," Frontiers in Physics, 7: 192, 2019, DOI=10.3389/fphy.2019.00192  ([[https://www.frontiersin.org/article/10.3389/fphy.2019.00192|Open Access]])     

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