Wiki

biochem_4c03_2021_winter

Fri, 08 Apr 2022 15:51:08 -0400

Example Page Group_1_TA_Agata_Kieliszek_Presentation_1 "Immune responses against SARS-CoV-2"; Group_1_TA_Agata_Kieliszek_Presentation_2 "Immune responses against SARS-CoV-2"; Group_2_TA_Sansi_Xing "Pathogenesis and transmission of SARS-CoV-2"; Group_2_TA_Sansi_Xing "Transgenic Mouse model of SARS-CoV-2 pathogenesis and transmission"; Group_3_TA_Agata_Kieliszek "Therapeutic targeting of SARS-CoV-2"; Group_3_TA_Agata_Kieliszek_Presentation_2 "Therapeutic Targeting of SARS-CoV-2"; Group_4_TA…

biochem_4c03_2022_winter

Wed, 19 Jan 2022 16:15:30 -0400

Example Page; Group_1_TA_Agata_Kieliszek_Immune_responses_against_SARS-CoV-2_Presentation_1; Group_2_TA_Nathan_Roberge_Pathogenesis_and_transmission_of_SARS-CoV-2_Presentation_1; Group_3_TA_Agata_Kieliszek_Therapeutic_targeting_of_SARS-CoV-2_Presentation_1; Group_4_TA_Nathan_Roberge_Vaccine_treatment_of_SARS-CoV-2_Presentation_1; Group_5_TA_Agata_Kieliszek_Stem_cell_models_and/or_therapies_for_SARS-CoV-2_Presentation_1; Group_6_TA_Nathan_Roberge_Diagnostics_of_SARS-CoV-2_Presentation_1; G…

biochem_4c03_2023_winter

Wed, 05 Apr 2023 13:17:14 -0400

Example Page; Group_1_TA_Karla_NatStructMolBiol_2021_28_8_Presentation_1; Group_2_TA_Karla_Nature_2020_584_348_Presentation_1; Group_3_TA_Karla_Nature_2019_567_471_Presentation_1; Group_4_TA_Matthew_Nature_2015_524_420_Presentation_1; Group_5_TA_Matthew_Nature_2019_576_389_Presentation_1; Group_6_TA_Matthew_Nature_2022_606_866_Presentation_1; Group_1_TA_Karla_NatStructMolBiol_2021_28_8_Presentation_2; Group_2_TA_Karla_Nature_2020_584_348_Presentation_2; Group_3_TA_Karla_Nature_2019_567_…

example_page

Wed, 06 Jan 2021 16:10:31 -0400

=== taken from What is Coronavirus? The name “Coronavirus” was found in the mid-1960s and it was derived from the “corona” or the crown-like shape observed for these viruses. Coronaviruses are a large family of viruses that cause illnesses. There are four main sub-grouping of the virus: Alpha, Beta, Gamma and Delta. Fun fact! Corona means crown in Latin. The name represents the crown-like spikes on the surface of …

group_1_ta_agata_kieliszek_immune_responses_against_sars-cov-2_presentation_1

Wed, 02 Feb 2022 21:48:32 -0400

Immune Response and Immunological Memory Following SARS-CoV-2 Infection Origin and Transmission of SARS-CoV-2 Coronavirus disease 2019 (COVID-19), is a contagious disease that, since December 2019, is an ongoing pandemic (Asselah et al., 2020). COVID-19 traces its origins to Wuhan, China, where several health facilities reported pneumonia cases of unknown origin, with patients exhibiting symptoms including fever, dry cough, sore throat, difficulty breathing, muscle pain and fatigue (Asselah…

group_1_ta_agata_kieliszek_immune_responses_against_sars-cov-2_presentation_2

Thu, 03 Mar 2022 01:52:24 -0400

SARS-CoV-2 Infection Generates Tissue-localized Immunological Memory in Humans Introduction Virus-specific circulating memory T cells, B cells, and antibodies SARS-CoV-2 infection induces an adaptive immune response in the body allowing T and B virus-specific cells to eliminate the virus in the respiratory tract. Protection from re-infection is associated with the generation of memory lymphocytes that continue to circulate the peripheral blood up to a year after the initial infection (Dan et …

group_1_ta_agata_kieliszek_presentation_1_immune_responses_against_sars-cov-2

Thu, 27 Jan 2022 15:11:21 -0400

COVID-19: The Immune Response in Pediatric and Adult Patients Origins of SARS-CoV-2 Our species, Homo sapiens, wasn’t always threatened by plagues when it first came into existence. Since the very beginning of our species' appearance, we have been always battling infectious diseases as individuals or small groups, just like any other species. (Harari, 2011) However, we started to face one of our deadliest enemies as a whole, the plagues and other pandemics, when we first domesticated some anim…

group_1_ta_agata_kieliszek_presentation_2_immune_responses_against_sars-cov-2

Sun, 27 Jun 2021 00:24:31 -0400

Overview of Immunology Cytokine Response Cytokines are small secreted proteins that are released by various cells and have a specific effect on the interactions and communication between cells (Zhang and An, 2009). IL-17A is a pro-inflammatory cytokine that causes epithelial cells to secrete neutrophil chemoattractant chemokines (Geha et al., 2017). Cells that produce IL-17A include TCRα/β T cells, TCRγ/δ T cells, and CD45+CD4+TCR−IL-7R+ type 3 innate lymphoid cells (ILC3s), which reside at m…

group_1_ta_karla_natstructmolbiol_2021_28_8_presentation_1

Thu, 02 Feb 2023 14:45:36 -0400

Gram-Negative Bacteria: Maintenance of Outer Membrane Asymmetry This project is based on Tang et al.'s article, “Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB.” Please follow this External Link to access the article.

group_1_ta_karla_natstructmolbiol_2021_28_8_presentation_2

Thu, 02 Mar 2023 19:16:46 -0400

Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB This project is based on Tang et al.'s article, “Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB.

group_2_ta_karla_nature_2020_584_348_presentation_1

Thu, 02 Feb 2023 13:22:02 -0400

Structure of the essential inner membrane lipopolysaccharide-PbgA complex Introduction The following content is an introduction to the 2020 paper published in Nature, “Structure of the essential inner membrane lipopolysaccharide-PbgA complex” by Clairfeuille et al. The paper discusses the role of PbgA in the LPS biosynthesis regulation and has key implications for novel antibiotic research in the future.

group_2_ta_karla_nature_2020_584_348_presentation_2

Thu, 02 Mar 2023 07:24:53 -0400

Structure of the essential inner membrane lipopolysaccharide-PbgA complex Introduction The following content is a look into the results of the 2020 paper published in Nature, “Structure of the essential inner membrane lipopolysaccharide-PbgA complex” by Clairfeuille et al. and its future implications. The paper discusses the role of PbgA in the LPS biosynthesis regulation and has key implications for novel antibiotic research in the future.

group_2_ta_nathan_roberge_pathogenesis_and_transmission_of_sars-cov-2_presentation_1

Thu, 03 Feb 2022 02:57:40 -0400

SARS-CoV-2: Pathogenesis & Transmission History of SARS-CoV-2 COVID-19 (otherwise known as Coronavirus disease 2019) is a contagious disease primarily affecting the respiratory system that is caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). In December 2019, the first human cases of the COVID-19 pandemic were identified in Wuhan, China. On January 30 2020, the World Health Organization declared COVID-19 as a Public Health Emergency of International Concern, and on March …

group_2_ta_nathan_roberge_pathogenesis_and_transmission_of_sars-cov-2_presentation_2

Thu, 03 Mar 2022 03:13:39 -0400

A cohort autopsy study defines COVID-19 systemic pathogenesis Introduction SARS-CoV-2 is a disease-causing pathogen from the coronaviridae family. It is closely related to SARS-CoV and MERS-CoV, however has lower mortality rates than the two and increased transmission rates. SARS-CoV-2 can lead to severe illness in certain individuals, usually ones who have pre-existing or underlying health conditions. This severe illness is almost always accompanied by a dysfunction in the lungs or other orga…

group_2_ta_sansi_xing_pathogenesis_and_transmission_of_sars-cov-2

Tue, 02 Feb 2021 07:20:27 -0400

Transmission and Pathogenesis of SARS-CoV-2 (Created by Kyle Cordeiro, Karol Derech, Cailyn Eley, Shahithra Kirubalingam & Abigail Oladesu) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the zoonotic respiratory disease that is now commonly known as Coronavirus disease 2019 shortened to Covid-19. Since the outbreak in December 2019 originating from Wuhan, China the virus has spread to 219 countries with almost 100 million cases that have been reported…

group_2_ta_sansi_xing_transgenic_mouse_model_of_sars-cov-2_pathogenesis_and_transmission

Tue, 02 Mar 2021 07:16:25 -0400

Transgenic Mouse Model of SARS-CoV-2 Pathogenesis and Transmission (Created by Kyle Cordeiro, Karol Derech, Cailyn Eley, Shahithra Kirubalingam & Abigail Oladesu) Abstract A transgenic mouse with human ACE2 infected with SARS-CoV-2 was developed as a disease model for COVID-19. The transgenic mice display many associated disease pathogenesis and phenotypes seen in humans. Using this model it was seen that:

group_3_ta_agata_kieliszek_presentation_2_therapeutic_targeting_of_sars-cov-2

Tue, 02 Mar 2021 00:15:14 -0400

Therapeutic Targeting of SARS-CoV-2 Created by: Michael D'Ercole, Onela Esho, Jasmine Leung, Meet Patel, and Amandeep Nagi Introduction Objective Pinto, et al. identify and describe both the binding properties and kinetics of neutralizing antibodies that target the S glycoprotein of SARS-CoV-2. The antibodies were identified from memory B cells of an individual who was infected with severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003.

group_3_ta_agata_kieliszek_therapeutic_targeting_of_sars-cov-2

Tue, 02 Feb 2021 07:24:17 -0400

Therapeutic Targeting of SARS-CoV-2 Created by: Michael D'Ercole, Onela Esho, Jasmine Leung, Meet Patel, and Amandeep Nagi Introduction Coronaviruses and SARS-CoV-2 SARS-CoV-2 is the zoonotic coronavirus that causes the disease COVID-19. More specifically, SARS-CoV-2 is a bat coronavirus as it originated in bats and was subsequently passed to humans (Fan et al., 2019). Although the news of a bat-originating virus shocked the general public, the fact that bats are viral reservoirs has been we…

group_3_ta_agata_kieliszek_therapeutic_targeting_of_sars-cov-2_presentation_1

Thu, 03 Feb 2022 02:33:52 -0400

Therapeutic Targeting of SARS-CoV-2 Created by: Carter Nattrass, Matthew Fernandes, Bisman Singh, Sehyun Cheon, Jessica Xing and Lamisa Syed Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel virus that is currently driving the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 is a highly transmissible virus that has caused 380 million infections and approximately 5 million deaths worldwide (WHO, 2022). COVID-19 is an upper respiratory illness th…

group_3_ta_agata_kieliszek_therapeutic_targeting_of_sars-cov-2_presentation_2

Thu, 03 Mar 2022 04:25:30 -0400

Therapeutic Targeting of SARS-CoV-2 Created by: Bisman Singh, Carter Nattrass, Jessica Xing, Lamisa Syed, Luke Cheon, & Matthew Fernandes Objective The Kim et al paper presents a novel monoclonal antibody (mAb) called CT-P59 against the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. After creating an antibody library from a recovered COVID-19 patient’s peripheral blood mononuclear cells, a high affinity monoclonal antibody, CT-P59, against the RBD was found (Kim et al., 2021).…

group_3_ta_karla_nature_2019_567_471_presentation_1

Thu, 02 Feb 2023 17:10:09 -0400

Structural basis for unidirectional export of lipopolysaccharide to the cell surface Tristan W. Owens, Rebecca J. Taylor, Karanbir S. Pahil, Blake R. Bertani, Natividad Ruiz, Andrew C. Kruse & Daniel Kahne | Nature volume 567, pages 550–553 (2019)

group_3_ta_karla_nature_2019_567_471_presentation_2

Thu, 02 Mar 2023 16:46:48 -0400

Structural Basis for Unidirectional Export of Lipopolysaccharide to the Cell Surface Tristan W. Owens, Rebecca J. Taylor, Karanbir S. Pahil, Blake R. Bertani, Natividad Ruiz, Andrew C. Kruse & Daniel Kahne | Nature volume 567, pages 550–553 (2019)

group_4_ta_matthew_nature_2015_524_420_presentation_1

Wed, 01 Feb 2023 23:15:14 -0400

The Structure and Mechanism of an Active, Lipid-Linked Flippase This Wiki page is adapted from a 2015 Nature publication by Perez et al. entitled “Structure and Mechanism of an Active, Lipid-Linked Oligosaccharide Flippase”. Read the full article here:

group_4_ta_matthew_nature_2015_524_420_presentation_2

Thu, 02 Mar 2023 13:42:38 -0400

group_4_ta_nathan_roberge_vaccine_treatment_of_sars-cov-2_presentation_1

Thu, 03 Feb 2022 08:30:29 -0400

By: Sarah Choe, Tianjia Cui, Elias Espinosa, Rachel Guan, Tim Wang SARS-CoV-2 Background The disease COVID-19 is caused by the virus SARS-CoV-2 and has infected millions of individuals worldwide. It has killed around 5,700,000 people and has shown no signs of slowing down (

group_4_ta_nathan_roberge_vaccine_treatment_of_sars-cov-2_presentation_2

Thu, 03 Mar 2022 08:17:55 -0400

By: Sarah Choe, Tianjia Cui, Elias Espinosa, Rachel Guan, Tim Wang Comparison of Immune Response for SARS-CoV-2 Naive and Experienced Individuals Following Two Doses of BNT162b2 Introduction It is without doubt that vaccines save lives. Pfizer-BioNTech developed the BNT162b2 vaccine against COVID-19, with the goal of eradicating SARS-CoV-2, and to reduce transmission rates worldwide (Pfizer, n.d.). As of March 2, 2022 there have been 437,333,859 confirmed COVID-19 cases, with 10,585,766,316 v…

group_4_ta_sansi_xing_presentation_2_vaccine_treatment_of_sars-cov-2

Tue, 02 Mar 2021 08:26:07 -0400

A Thermostable mRNA Vaccine against COVID-19 Introduction mRNA Vaccines mRNA vaccines have emerged as a leading contender in the fight against the COVID-19 pandemic. In Canada, as of February 2021, two of the three vaccines approved for emergency-use against COVID-19 are mRNA-based. They include Pfizer-BioNTech’s COVID-19 vaccine BNT162b2, and Moderna’s COVID-19 vaccine mRNA-1273 (Government of Canada, 2021). Unlike traditional vaccines that utilize a weakened pathogen or antigens, mRNA vacci…

group_4_ta_sansi_xing_vaccine_treatment_of_sars-cov-2

Tue, 02 Feb 2021 06:50:44 -0400

Template from COVID-19 Vaccine The global spread of coronavirus has led to a drastic need for a vaccine. In early January 2020, The World Health Organization (WHO) announced reports of pneumonia due to a novel coronavirus in Wuhan, China (American Journal of Managed Care [AJMC], 2020). By January 31, the WHO declared the spread of coronavirus as a public health emergency (AJMC, 2020). The novel coronavirus was iden…

group_5_ta_agata_kieliszek_presentation_2_stem_cell_models_and_or_therapies_for_sars-cov-2

Mon, 01 Mar 2021 22:42:20 -0400

Organoid Models for SARS-CoV-2 Created By: Jasmit Dhaliwal, Cynthia Yuanxin Gu, Pavlo Navrota, Jasmine Soomal Introduction In “A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids” by Yang et al., the authors aimed to discover a physiologically relevant human model to study SARS-CoV-2 infection. A library of cell and organoids was generated from hPSCs, which were then infected with the virus to evaluate permissiveness.…

group_5_ta_agata_kieliszek_stem_cell_models_and_or_therapies_for_sars-cov-2

Tue, 02 Feb 2021 14:18:33 -0400

Organoid Models for SARS-CoV-2 Created By: Jasmit Dhaliwal, Cynthia Yuanxin Gu, Pavlo Navrota, Jasmine Soomal Introduction Organoids are three-dimensional stem cell derived miniature organs produced in vitro. They are an important tool for modeling and finding potential treatments for diseases such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic. Due to the physiological similarities organoids have with human tissue, they are better able to …

group_5_ta_agata_kieliszek_stem_cell_models_and_or_therapies_for_sars-cov-2_presentation_1

Thu, 03 Feb 2022 12:01:09 -0400

Stem Cell Models and/or Therapies for SARS-CoV-2 Created By: Edward Shen, Sameer Hayat, Mingyuan Wan, Talitha Ling Introduction Mesenchymal stem cells (MSCs) are multipotent stem cells that function to regenerate tissues and assist in immune regulation (Zhu et al., 2021). With increasing recognition of the immunological role of MSCs and their ability to differentiate into a vast array of tissues such as bone, cartilage, and adipose tissue, MSCs have gained traction in the scientific community…

group_5_ta_agata_kieliszek_stem_cell_models_and_or_therapies_for_sars-cov-2_presentation_2

Thu, 03 Mar 2022 04:11:55 -0400

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms By: Sameer Hayat, Fitz Wan, Edward Shen, Talitha Ling Introduction Mesenchymal Stem Cells Mesenchymal stem cells (MSCs) are multipotent stromal stem cells that can differentiate into mesodermal lineages such as adipocytes, osteocytes, and chondrocytes (Ullah et al., 2015). MSCs have immunomodulatory and regenerative properties which have garnered the interest of researchers as a pro…

group_5_ta_matthew_nature_2019_576_389_presentation_1

Thu, 02 Feb 2023 15:09:28 -0400

Antibiotics Against Gram-Negative Bacteria Researchers Researchers all over the world work hard in the discovery of antibiotics, one such researcher is Dr. Kim Lewis, leader of the Lewis Lab at Northeastern University where he is a distinguished professor with expertise in molecular microbiology. Dr. Kim Lewis’ lab consists of the Lewis Lab which studies persister cells responsible for tolerance to antibiotics, uncultured bacteria of the environment and the microbiome. It also includes the ant…

group_5_ta_matthew_nature_2019_576_389_presentation_2

Thu, 02 Mar 2023 14:42:22 -0400

DAROBACTIN The paper titled "A new antibiotic selectively kills Gram-negative pathogens" can be found by the link. Introduction Infectious diseases are a significant cause of death worldwide, accounting for approximately one third of all deaths among the top ten leading causes of death (Center for Disease Control (CDC), 1999). Currently, the main treatment for infectious diseases is prescribing antibiotics; however, the rate of resistance to antibiotics by bacteria is increasing whilst the pr…

group_6_ta_matthew_nature_2022_606_866_presentation_1

Thu, 02 Feb 2023 14:19:11 -0400

Peptidoglycan maturation controls outer membrane protein assembly See the article by Mamou et. al Created By: Mathias Wang, Jake Weinstein, Leon Xu, Marius Ygonia, Ziran Yin, Junyi Zhang, Amy Zhao, Ray Zhu Main Authors and Backgrounds Federico Corona As one of the first two authors and equal contributor to Mamou, Federico Corona is a post-doctoral researcher at Newcastle University where he obtained a Marie-Curie fellowship. With a background in biology and a master's in cellular and molec…

group_6_ta_matthew_nature_2022_606_866_presentation_2

Thu, 02 Mar 2023 09:09:32 -0400

Peptidoglycan maturation controls outer membrane protein assembly Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G. Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J. Knowles, Colin Kleanthous & Waldemar Vollmer | Nature volume 606, pages 953–959 (2022)

group_6_ta_nathan_roberge_diagnostics_of_sars-cov-2_presentation_1

Wed, 02 Feb 2022 21:57:43 -0400

Diagnostics of SARS-CoV-2 Created by: Anastasiya Dudnyk, Gurkaran Chhaggar, Jessica Bensky, Lan Yang, Teng Yi Huang SARS-CoV-2 Background Information The novel coronavirus is an enveloped virus with a positive single stranded RNA genome. Its viral genome encodes many important proteins among which include RNA-dependent RNA polymerase (RdRp), spike (S), membrane (M), envelope (E), and the nucleocapsid (N) proteins (Malik, 2020). The viral entry into host cells is facilitated by the attachment …

group_6_ta_nathan_roberge_diagnostics_of_sars-cov-2_presentation_2

Wed, 02 Mar 2022 21:46:09 -0400

SARS-CoV-2 Diagnostic Using an Electrochemical Aptamer-Based Sensor Created by: Anastasiya Dudnyk, Bonnie Yang, Gurkaran Chhaggar, Jessica Bensky, Tony Huang Background of Diagnostics Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the seventh coronavirus known to infect humans. The remaining six are HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1, SARS-CoV (which caused severe acute respiratory…

group_6_ta_sansi_xing_diagnostics_of_sars-cov-2

Sat, 27 Feb 2021 20:09:40 -0400

Diagnostics of SARS-CoV-2 Created by: Leena Dhaliwal, Adnan Hassanali, Tristen Nimojan, Abdullah Syeddan What is SARS-CoV-2? Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that caused a disease outbreak which originated in China in late 2019 (Sheposh, 2021). The name of the disease caused by this virus is coronavirus disease 2019, more commonly known as COVID-19 (Sheposh, 2021). This outbreak quickly spread across the globe and was declared a global pandemic by …

group_6_ta_sansi_xing_presentation_2_crispr-cas12-based_detection_of_sars-cov-2

Tue, 02 Mar 2021 12:00:13 -0400

CRISPR–Cas12-Based Detection of SARS-CoV-2 Created by: Leena Dhaliwal, Adnan Hassanali, Tristen Nimojan, Abdullah Syeddan Introduction Within the last 40 years, there have been many large-scale epidemics from viruses such as HIV, SARS and Middle East respiratory syndrome coronaviruses, 2009 pandemic influenza H1N1 virus, Ebola virus, Zika virus, and most recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Broughton et al., 2020). Like all the other epidemics, the pand…

start

Thu, 12 Jan 2023 12:47:51 -0400

BIOCHEM_4C03 Wiki You must LOG IN using your MAC ID to proceed any further and read/edit any wiki pages. Biochem_4C03_2021_Winter Biochem_4C03_2022_Winter Biochem_4C03_2023_Winter